A case of nasal low-grade non-intestinal-type adenocarcinoma with aberrant CDX2 expression and a novel SYN2-PPARG gene fusion in a 13-year-old girl

  • Gwyneth Shook Ting Soon
  • Kenneth Tou En Chang
  • Chik Hong Kuick
  • Fredrik PeterssonEmail author
Brief Report


We report the first patient (a 13-year-old girl) with a sinonasal low-grade non-intestinal-type adenocarcinoma showing aberrant CDX2 expression both within morular areas and in the tubular component and demonstrate for the first time a SYN2-PPARG gene fusion in this tumor type. The tumor arose from the nasal septum and had not spread beyond the nasal cavity.


Sinonasal Adenocarcinoma Intestinal Non-intestinal CDX2 SYN2-PPARG gene fusion 


Authors’ contributions

Dr. Soon wrote the manuscript; Dr. Chang and Mr. Kuick conducted the molecular analysis; and Dr. Petersson reviewed the specimen, made the diagnosis, is responsible for the light microscopical and immunohistochemical pictures, and edited and revised the manuscript. All authors gave final their approval for publication.

Compliance with ethical standard

It is our institution’s policy not to require formal ethical approval for reports on up to two patients.

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Gwyneth Shook Ting Soon
    • 1
  • Kenneth Tou En Chang
    • 2
  • Chik Hong Kuick
    • 2
  • Fredrik Petersson
    • 1
    Email author
  1. 1.Department of Pathology, National University HospitalNational University Health SystemSingaporeSingapore
  2. 2.Department of Pathology and Laboratory MedicineKK Women’s and Children’s HospitalSingaporeSingapore

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