Letter to the editor: reply to Antonio Ieni “Intratumoral HER2 heterogeneity in early gastric carcinomas: potential bias in therapeutical management”
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Kazuki Kanayama: writing—original draft, writing–review and editing.
Hiroshi Imai: writing—review and editing.
Eri Usugi: writing—review and editing.
Taizo Shiraishi: writing—review and editing.
Yoshifumi S. Hirokawa: writing—original draft, writing—review and editing.
Masatoshi Watanabe: writing—review and editing.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflicts of interest.
- 1.Ieni A, Barresi V, Caltabiano R, Caleo A, Bonetti LR, Lanzafame S, Zeppa P, Caruso RA, Tuccari G (2014) Discordance rate of HER2 status in primary gastric carcinomas and synchronous lymph node metastases: a multicenter retrospective analysis. Int J Mol Sci 15:22331–22341. https://doi.org/10.3390/ijms151222331 CrossRefGoogle Scholar
- 4.Kanayama K, Imai H, Yoneda M, Hirokawa YS, Shiraishi T (2016) Significant intratumoral heterogeneity of human epidermal growth factor receptor 2 status in gastric cancer: a comparative study of immunohistochemistry, FISH, and dual-color in situ hybridization. Cancer Sci 107:536–542. https://doi.org/10.1111/cas.12886 CrossRefGoogle Scholar
- 7.Tanabe S, Hirabayashi S, Oda I, Ono H, Nashimoto A, Isobe Y, Miyashiro I, Tsujitani S, Seto Y, Fukagawa T, Nunobe S, Furukawa H, Kodera Y, Kaminishi M, Katai H (2017) Gastric cancer treated by endoscopic submucosal dissection or endoscopic mucosal resection in Japan from 2004 through 2006: JGCA nationwide registry conducted in 2013. Gastric Cancer 20:834–842. https://doi.org/10.1007/s10120-017-0699-4 CrossRefGoogle Scholar