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Metastatic breast carcinoma to the urinary bladder—a report of 11 cases including a tumor to tumor metastasis

  • Gang WangEmail author
  • Chen Zhou
  • Christopher Conklin
  • Malcolm M. Hayes
  • Carlos F. Villamil
  • Avrum Ostry
  • Edward C. Jones
Original Article
  • 26 Downloads

Abstract

Metastatic breast carcinoma to the urinary bladder is rare. Eleven cases of metastatic breast carcinoma to the bladder are described in this report, including one case with a tumor to tumor metastasis. The patients ranged from 51 to 83 years of age. The time intervals between the diagnosis of primary breast cancer and the occurrence of bladder metastases ranged from 41 to 336 months. There were seven cases of invasive ductal carcinoma and four cases of invasive lobular carcinoma. In one case, a lobular carcinoma of the breast metastasized to a concurrent squamous cell carcinoma of the bladder. The immunophenotypic status of estrogen receptor and Her2 expression of the metastatic carcinomas were all concordant with the primary tumors. In nine patients with follow-up available, seven patients died of the disease ranging from 1 to 23 months after the diagnosis of the bladder metastasis and two patients were alive at 5 months of follow-up. To date, this report is the largest single series of patients with breast carcinoma metastatic to the bladder. It is the first reported instance of lobular carcinoma of the breast metastasizing to a squamous cell carcinoma of the bladder.

Keywords

Metastasis Breast carcinoma Bladder Tumor to tumor metastasis 

Notes

Author contributions

Gang Wang conceived and designed the study, collected data, and wrote, edited, and reviewed the manuscript. Chen Zhou, Christopher Conklin, Malcolm Hayes, Carlos Villamil, Avrum Ostry, and Edward Jones collected data and edited and reviewed the manuscript. All authors gave final approval for publication. Gang Wang takes full responsibility for the work as a whole, including the study design, access to data, and the decision to submit and publish the manuscript.

Compliance with ethical standards

The current study was approved by the institutional review board of the University of British Columbia.

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of PathologyBC Cancer Vancouver CentreVancouverCanada
  2. 2.Department of Pathology and Laboratory MedicineUniversity of British ColumbiaVancouverCanada
  3. 3.Department of PathologySt. Paul’s HospitalVancouverCanada
  4. 4.Department of PathologyVancouver General HospitalVancouverCanada

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