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High expression of cytoplasmic polyadenylation element-binding protein 4 correlates with poor prognosis of patients with colorectal cancer

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Cytoplasmic polyadenylation element-binding protein 4 (CPEB4), a zinc-finger-containing sequence-specific RNA-binding protein, has been associated with tumor proliferation, invasion, and migration. Expression of CPEB4 and its prognostic significance in human colorectal cancer (CRC) have not been studied. The aim of the present study was to investigate expression of CPEB4 and its prognostic significance in CRC. Expression of CPEB4 in CRC tissues from two independent cohorts was examined by immunohistochemistry. Prognostic significance was analyzed using receiver operating characteristic curve analysis, Kaplan-Meier curves, and Cox regression analysis. High expression of CPEB4 was observed in 14.8 % of CRCs in the training cohort and 12.2 % of CRCs in the validation cohort. High expression of CPEB4 was significantly correlated with the pM classification, TNM stage, and poorer overall survival in both cohorts. Through multivariate Cox regression analysis, high expression of CPEB4 was found to be an independent prognostic biomarker for overall survival in CRC patients. High expression of CPEB4 may be an independent and useful biomarker for predicting the poor survival of patients with CRC.

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Author information

Correspondence to Ping Lan or Jianping Wang.

Ethics declarations

This study was approved by the IRB of the Sixth Affiliated Hospital and Cancer Center, Sun Yat-sen University.

Conflict of interest

The authors declare that they have no conflict of interest.

Declaration of funding interests

This work is Supported by the National Natural Science Foundation of China (81,400,604 and 81,402,412).

Additional information

Xiaosheng He, Xutao Lin, and MuYan Cai contributed equally to this paper.

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He, X., Lin, X., Cai, M. et al. High expression of cytoplasmic polyadenylation element-binding protein 4 correlates with poor prognosis of patients with colorectal cancer. Virchows Arch 470, 37–45 (2017). https://doi.org/10.1007/s00428-016-2037-3

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Key words

  • Colorectal cancer
  • Cytoplasmic polyadenylation element-binding proteins
  • Prognosis
  • Biomarker