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Clinicopathologic characteristics of pleomorphic carcinoma of the breast


Pleomorphic carcinoma of the breast is considered a rare variant of high-grade ductal NOS carcinoma (NOS-IDC), and the prognosis is poor. However, its clinicopathologic features are not well-characterized. Using the criteria delineated in the World Health Organization breast tumor classification of 2003, ten cases of pleomorphic carcinoma were identified from 9794 NOS-IDC in our archived materials that were originally diagnosed as high-grade infiltrating ductal carcinoma of breast. To investigate the clinicopathologic characteristics and to elucidate the histologic diagnosis and differential diagnosis of this entity, we reviewed the pathology manifestations and clinical features of these cases and examined the tumor expression of ER, PR, PCNA, AE1/AE3, p53, S-100, C-erbB-2, EMA, p63, and Bcl-2 by immunohistochemistry.

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We thank Prof. Vincenzo Eusebi, M.D., Director and Professor of Anatomic and Cytopatholofy section of Pathology “M, Malpighi”, University of Bologna, Bologna, Italy and Xinmin Zhang, M.D., Department of Pathology and Laboratory Medicine, Temple University Hospital, Philadelphia, USA for their critical review for this manuscript. This study was supported by fundings from Science Foundation of Tianjin Medical University(2006KY24) and National Natural Science Foundation of China (30600225 and 30470667), Program for Changjiang Scholars and Innovative Research Team in University (IRT0743), National “863” Program of China (2006AA02A249), and National “973” Program of China (2009CB521700).

Conflict of interest statement

We declare that we have no conflict of interest.

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Correspondence to Li Fu.

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Zhao, J., Lang, R., Guo, X. et al. Clinicopathologic characteristics of pleomorphic carcinoma of the breast. Virchows Arch 456, 31–37 (2010).

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  • Breast
  • Carcinoma
  • Pleomorphic carcinoma
  • Histological classification
  • Clinicopathologic feather
  • Morphology