Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Absence of mismatch repair deficiency in gastric lymphoma: an immunohistochemical study of mlh1 and msh2 protein expression

This is a preview of subscription content, log in to check access.

Fig. 1
Fig. 2


  1. 1.

    Chapusot C, Martin L, Puig PL, Ponnelle T, Cheynel N, Bouvier AM, Rageot D, Roignot P, Rat P, Faivre J, Piard F (2004) What is the best way to assess microsatellite instability status in colorectal cancer? Study on a population base of 462 colorectal cancers. Am J Surg Pathol 28:1553–1559

  2. 2.

    Duval A, Raphael M, Brennetot C, Poirel H, Buhard O, Aubry A, Martin A, Krimi A, Leblond V, Gabarre J, Davi F, Charlotte F, Berger F, Gaidano G, Capello D, Canioni D, Bordessoule D, Feuillard J, Gaulard P, Delfau MH, Ferlicot S, Eclache V, Prevot S, Guettier C, Lefevre PC, Adotti F, Hamelin R (2004) The mutator pathway is a feature of immunodeficiency-related lymphomas. Proc Natl Acad Sci USA 101:5002–5007

  3. 3.

    Reitmair AH, Schmits R, Ewel A, Bapat B, Redston M, Mitri A, Waterhouse P, Mittrucker HW, Wakeham A, Liu B, Thomason A, Griesser H, Gallinger S, Ballhausen WG, Fishel R, Mak TM (1995) MSH2 deficient mice are viable and susceptible to lymphoid tumours. Nat Genet 11:64–70

  4. 4.

    Rigau V, Sebbagh N, Olschwang S, Paraf F, Mourra N, Parc Y, Flejou JF (2003) Microsatellite instability in colorectal carcinoma. The comparison of immunohistochemistry and molecular biology suggests a role for hMSH6 immunostaining. Arch Pathol Lab Med 127:694–700

  5. 5.

    Starostik P, Greiner A, Schwarz S, Patzner J, Schultz A, Muller-Hermelink HK (2000) The role of microsatellite instability in gastric low- and high-grade lymphoma Development. Am J Pathol 157:1129–1136

Download references

Author information

Correspondence to P. Cuilliere-Dartigues.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Cuilliere-Dartigues, P., Fabiani, B., Dumont, S. et al. Absence of mismatch repair deficiency in gastric lymphoma: an immunohistochemical study of mlh1 and msh2 protein expression. Virchows Arch 451, 983–984 (2007). https://doi.org/10.1007/s00428-007-0500-x

Download citation


  • Malt Lymphoma
  • Gastric Lymphoma
  • Gastric Malt Lymphoma
  • Mismatch Repair Deficiency
  • Inconclusive Case