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Virchows Archiv

, Volume 451, Issue 6, pp 1091–1093 | Cite as

Small intestinal CD4+ T-cell lymphoma: a rare distinctive clinicopathological entity associated with prolonged survival

  • Magali SvrcekEmail author
  • Laurent Garderet
  • Virginie Sebbagh
  • Michelle Rosenzwajg
  • Yann Parc
  • Monique Lagrange
  • Malika Bennis
  • Anne Lavergne-Slove
  • Jean-François Fléjou
  • Bettina Fabiani
Letter to the Editor

Dear Editor,

Intestinal T-cell lymphomas are rare and heterogeneous. Most of them are localised high-grade large cell lymphomas and carry a poor prognosis. The WHO classification only recognises one distinct entity of intestinal T-cell lymphoma, called “enteropathy-associated T-cell lymphoma” [5]. This lymphoma arises in pre-existing celiac disease. The neoplastic cells infiltrate the overlying epithelium, mimicking normal intraepithelial lymphocytes (IELS). They are CD3+, CD5−, CD7+, CD8−/+ and also express the homing receptor CD103 antigen, typically seen in normal and malignant intraepithelial T lymphocytes. CD4 is always negative.

In 1999, Carbonnel et al. [1] reported four patients with clinico-pathological features suggesting a new distinct entity defining extensive small intestinal CD4+ T-cell lymphoma.

We had the opportunity to diagnose an additional case of this T-cell low grade lymphoma in a patient without any evidence of celiac disease, associated with prolonged survival.

In...

Keywords

Celiac Disease Granulomatous Reaction Ileal Resection Cutaneous Lymphoma Polyclonal Hypergammaglobulinemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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    Carbonnel F, d’Almagne H, Lavergne A, Matuchansky C, Brouet JC, Sigaux F, Beaugerie L, Nemeth J, Coffin B, Cosnes J, Gendre JP, Rambaud JC (1999) The clinicopathological features of extensive small intestinal CD4 T cell infiltration. Gut 45:662–667PubMedCrossRefGoogle Scholar
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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Magali Svrcek
    • 1
    • 2
    Email author
  • Laurent Garderet
    • 2
    • 3
  • Virginie Sebbagh
    • 2
    • 4
  • Michelle Rosenzwajg
    • 2
    • 5
  • Yann Parc
    • 2
    • 6
  • Monique Lagrange
    • 2
    • 5
  • Malika Bennis
    • 2
    • 6
  • Anne Lavergne-Slove
    • 7
  • Jean-François Fléjou
    • 1
    • 2
  • Bettina Fabiani
    • 1
    • 2
  1. 1.Service d’Anatomie et Cytologie PathologiquesHôpital Saint-Antoine, AP-HP, ParisParis cedex 12France
  2. 2.Université Pierre et Marie CurieParis 6France
  3. 3.Service d’ HématologieAP-HP, Hôpital Saint-AntoineParis cedex 12France
  4. 4.Service d’ Gastroentérologie et NutritionAP-HP, Hôpital Saint-AntoineParis cedex 12France
  5. 5.Service d’ Immunologie et Hématologie BiologiquesAP-HP, Hôpital Saint-AntoineParis cedex 12France
  6. 6.Service d’ Chirurgie ViscéraleAP-HP, Hôpital Saint-AntoineParis cedex 12France
  7. 7.Service d’Anatomie et Cytologie PathologiquesAP-HP, Hôpital LariboisièreParis cedex 10France

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