Virchows Archiv

, Volume 448, Issue 3, pp 379–380 | Cite as

Small-cell variant of renal oncocytoma with dominating solid growth pattern: a potential diagnostic pitfall

  • Gaetano MagroEmail author
  • Marina Paola Gardiman
  • Maria Rosa Lopes
  • Michal Michal
Letter to the Editor

Dear Editor,

Renal oncocytoma is a distinct benign renal tumour accounting approximately for 4% of all renal tumours. This neoplasm is easily recognizable in its classic form—polygonal cells with abundant granular eosinophilic cytoplasm, arranged in tubuloalveolar cystic pattern—whereas diagnostic difficulties may arise when it exhibits small cells with scant cytoplasm and hyperchromatic nuclei (so-called “oncoblasts”) [2]. Although these small cells are rarely detectable in an otherwise classic renal oncocytoma [1, 3], there is the possibility that they may represent the dominating cell component [2]. One of us (MM), by reviewing a large series of renal oncocytomas, found only 3 out of 134 tumours with a prominent (80% of the entire tumours in two cases and 50% in the other case) small-cell component, and the term “small-cell variant of renal oncocytoma” was proposed for these cases [2]. We report a rare case of renal oncocytoma with a predominant small-cell component, accounting for...


Oncocytoma Small cell variant Kidney 


  1. 1.
    Amin MB, Crotty TB, Tickoo SK, Farrow G (1997) Renal oncocytoma. A reappraisal of morphologic features with clinicopathologic findings in 80 cases. Am J Surg Pathol 21:1–12CrossRefPubMedGoogle Scholar
  2. 2.
    Hes O, Michal M, Boudova L, Mukensnabl, Kinkor Z, Miculka P (2001) Smal cell variant of renal oncocytoma—a rare and misleading type of benign renal tumour. Int J Surg Pathol 9:215–222PubMedCrossRefGoogle Scholar
  3. 3.
    Perez-Ordonez B, Hamed G, Campbell S, Erlandson RA, Russo P, Gaudin PB, Reuter VE (1997) Renal oncocytoma: a clinicopathologic study of 70 cases. Am J Surg Pathol 21:871–883PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Gaetano Magro
    • 1
    Email author
  • Marina Paola Gardiman
    • 2
  • Maria Rosa Lopes
    • 3
  • Michal Michal
    • 4
  1. 1.Dipartimento G.F. Ingrassia, Anatomia PatologicaUniversità di CataniaCataniaItaly
  2. 2.Dipartimento Scienze Oncologiche, Anatomia PatologicaUniversità di PadovaPaduaItaly
  3. 3.Unità Operativa di UrologiaOspedale Vittorio Emanuele di GelaCaltanissettaItaly
  4. 4.Sikl’s Department of PathologyCharles University HospitalPilsenCzech Republic

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