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Carcinoma ex-pleomorphic adenoma of the breast. Report of three cases suggesting a relationship to metaplastic carcinoma of matrix-producing type


Three cases of carcinoma ex-pleomorphic adenoma of the breast are reported. Patients were 82, 60 and 56 years old and presented with a breast lump. All tumours showed areas of pleomorphic adenoma adjacent to typical areas of malignant transformation. These cases add to the spectrum of tumours shared by breast and salivary gland. The relationship between these neoplasms and metaplastic carcinoma of matrix-producing type is discussed.

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Part of the work was financed with grants from MURST, Rome (40%), and the University of Bologna (ex 60%).

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Correspondence to Malcolm M. Hayes.

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Hayes, M.M., Lesack, D., Girardet, C. et al. Carcinoma ex-pleomorphic adenoma of the breast. Report of three cases suggesting a relationship to metaplastic carcinoma of matrix-producing type. Virchows Arch 446, 142–149 (2005).

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  • Pleomorphic adenoma
  • Breast carcinoma
  • Metaplastic carcinoma