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CD10 expression in diffuse large B-cell lymphomas does not influence survival


CD10 expression is considered as a marker of centrofollicular-derived diffuse large B-cell lymphomas (DLBCL). The aim of our study was to determine retrospectively among 98 patients with DLBCL, enrolled in the LNH93 trial of the Groupe d’Etude des Lymphomes de l’Adulte (GELA) and homogeneously treated with high-dose cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP)-like regimen [doxorubicin, cyclophosphamide, vindesine, bleomycin and prednisone (ACVBP)], the expression of CD10 using immunohistochemistry and its correlation with morphological features and clinical parameters. Of the 98 patients studied, 33 (34%) expressed CD10. There was no correlation among clinical parameters, International Prognostic Index risk groups and CD10 expression, with the exception of lactic dehydrogenase levels, which were lower in CD10-negative cases (P=0.005). There was no significant correlation between CD10 expression and morphological subtyping of DLBCL. Indeed, centrofollicular-derived DLBCL may present with numerous immunoblasts or as an immunoblastic lymphoma. Overall survival rate and event-free survival were not significantly different according to CD10 expression (P=0.44 and P=0.34 respectively). Therefore, it appears that CD10 expression does not influence survival or event-free survival in DLBCL.

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We thank Nicolas Nio, who performed the statistical analysis, Pauline Brice, Karen Leroy-Viard and Gilles Salles for critical review of the manuscript and Chafika Copeaux for technical help. Acknowledgements of source of support: this study was supported by grants from the Ministère de la Santé (PHRC AOM 95061), and from Amgen-Roche, Neuilly sur Seine, France.

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Correspondence to Thierry J. Molina.



The following investigators participated in the study: N. Albin, C. Allard, M. Aoudjane, D. Assouline, M. Attal, B. Audhuy, M.Azagury, J.C. Barats, C. Beaumont, E. Baumelou, P. Biron, M. Blanc, D. Bordessoule, A. Bosly, K. Bouabdallah, C. Bouleuc, P. Bourquard, P. Bourquelot, F. Boué, O. Boulat, P. Brice, J. Brière, G. Brun, D. Caillot, O. Casasnovas, P. Carde, S. Castaigne, S. Chèze, B. Christian, B. Coiffier, P. Colin, C. Collet, T. Conroy, T. Cosnard, B. Corront, H. Curé, V. Delwail, L. Detourmignies, A. Devidas, H. Dombret, J.F. Dor, C. Doyen, F. Dreyfus, S. Dront, G. Dupont, B. Dupriez, J.C. Eisenmann, M. Fabbro, C. Fermé, G. Fillet, M. Flesch, C. Fruchart, J. Gabarre, C. Haioun, R. Herbrecht, O. Hermine, A. Huyn, F. Huguet, M. Janvier, E. Jourdan, J.M. Karsenti, Y. Kerneis, F. Kohser, V. Leblond, P. Lederlin, S. Lefort, P. Lenain, G. Lepeu, S. Lepretre, X. Levaltier, A. Le Rol, G. Marit, C. Martin, F. Mayer, C. Nouvel, P.Morel, M. Moriceau, J.N. Munck, G. Nedellec, F. Offner, J.M. Pavlovitch, I. Plantier, P.Y. Péaud, A.M. Peny, J. Pico, C. Platini, J.P. Pollet, B. Quesnel, O. Reman, B. Richard, R. Riou, P. Rodon, B. Salles, G. Salles, C. Sarazin, D. Schlaifer, C. Sebban, M. Simon, P. Solal-Céligny, J.J. Sotto, A. Stamatoullas, C. Soussain, G. Tertian, A. Thyss, H. Tilly, J.D. Tigaud, G. Tobelem, P. Travade, A. Van Hoof, B. Varet, A. Zaniboni and J.M. Zini.

The following pathologists actively participated to the trial and provided the slides: R. Angonin, I. Abd Alsamad, A. C. Baglin, F. Berger, N. Brousse, J.-P. Brouland, P. Brousset, D. Canioni, O. Casiraghi, D. Cazals-Hatem, A. M. Chesneau, F. Charlotte, M.-P. Chenard-Neu, C. Copie-Bergman, M.-C. Copin, M. Delos, C. Duval, G. Delsol, J. Diebold, C. Fromentin, F. Galateau, B. Gasser, B. Gosselin, C. Guettier, J. Hamels, N. Horschowski, R. Jeandel, J. P. Knopf, E. Labouyrie, C. Legendre, A. Letourneau, A. de Mascarel, V. Meignin, M. Parrens, B. Petit, M. Raphael, M. C. Raymond-Gelle, P. Straub, Y. Theate, S. Thiebaut, M. Tulliez and L. Xerri.

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Fabiani, B., Delmer, A., Lepage, E. et al. CD10 expression in diffuse large B-cell lymphomas does not influence survival. Virchows Arch 445, 545–551 (2004). https://doi.org/10.1007/s00428-004-1129-7

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  • Lymphoma
  • Tumor marker
  • Clinical pathology