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An amphioxus Krox gene: insights into vertebrate hindbrain evolution

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Abstract 

The transcription factor Krox-20 has roles in the maintenance of segmentation and specification of segment identity in the vertebrate hindbrain. Overt hindbrain segmentation is a vertebrate novelty, and is not seen in invertebrate chordates such as amphioxus and tunicates. To test if the roles of Krox-20 are also derived, we cloned a Krox-20 related gene, AmphiKrox, from amphioxus. AmphiKrox is related to a small family of vertebrate Krox genes and is expressed in the most anterior region of the amphioxus brain and in the club shaped gland, a secretory organ that develops in the anterior pharynx. Neither expression domain overlaps with the expression of AmphiHox-1, -2, -3 or -4, suggesting that the roles of Krox-20 in hindbrain segmentation and in Hox gene regulation were acquired concomitant with the duplication of Krox genes in vertebrate evolution.

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Received: 10 April 2000 / Accepted: 25 May 2000

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Knight, R., Panopoulou, G., Holland, P. et al. An amphioxus Krox gene: insights into vertebrate hindbrain evolution. Dev Gene Evol 210, 518–521 (2000). https://doi.org/10.1007/s004270000092

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  • Key words Krox-20
  • Hox
  • amphioxus
  • Hindbrain
  • Vertebrate evolution