Many kinds of transcription factors and regulators play key roles in a variety of developmental processes. In the present survey, genes encoding proteins with conserved HMG-box, bZip domains, and some types of zinc finger motifs were surveyed in the completely sequenced genome of Ciona intestinalis. In the present analysis, 21 HMG-box-containing genes and 26 bZip genes were identified as well as four small groups of zinc finger genes in the Ciona genome. The results also showed that a less redundant set of genes is present in the Ciona genome compared with vertebrate genomes. In addition, cDNA clones for almost all genes identified have been cloned and distributed as a "Ciona intestinalis Gene Collection Release I". The present comprehensive analysis therefore provides a means to study the role of these transcription factors in developmental processes of basal chordates.
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This research was supported by Grants-in-Aid for Scientific Research from MEXT and JSPS, Japan to Y.S. (14704070) and N.S. (12202001). K.K. was a Postdoctoral Fellow of JSPS with research grant (14061430). We thank Kazuko Hirayama, Chikako Imaizumi, Asako Fujimoto, and Hisayoshi Ishikawa for their technical support.
The first two authors equally contributed to this work.
Edited by D. Tautz
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Yamada, L., Kobayashi, K., Degnan, B. et al. A genomewide survey of developmentally relevant genes in Ciona intestinalis . Dev Genes Evol 213, 245–253 (2003). https://doi.org/10.1007/s00427-003-0316-x
- Basal chordates
- Ciona intestinalis
- Genomewide survey
- HMG transcriptional regulators