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A genomewide survey of developmentally relevant genes in Ciona intestinalis

IV. Genes for HMG transcriptional regulators, bZip and GATA/Gli/Zic/Snail

Abstract

Many kinds of transcription factors and regulators play key roles in a variety of developmental processes. In the present survey, genes encoding proteins with conserved HMG-box, bZip domains, and some types of zinc finger motifs were surveyed in the completely sequenced genome of Ciona intestinalis. In the present analysis, 21 HMG-box-containing genes and 26 bZip genes were identified as well as four small groups of zinc finger genes in the Ciona genome. The results also showed that a less redundant set of genes is present in the Ciona genome compared with vertebrate genomes. In addition, cDNA clones for almost all genes identified have been cloned and distributed as a "Ciona intestinalis Gene Collection Release I". The present comprehensive analysis therefore provides a means to study the role of these transcription factors in developmental processes of basal chordates.

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Acknowledgements

This research was supported by Grants-in-Aid for Scientific Research from MEXT and JSPS, Japan to Y.S. (14704070) and N.S. (12202001). K.K. was a Postdoctoral Fellow of JSPS with research grant (14061430). We thank Kazuko Hirayama, Chikako Imaizumi, Asako Fujimoto, and Hisayoshi Ishikawa for their technical support.

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Correspondence to Yutaka Satou.

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The first two authors equally contributed to this work.

Edited by D. Tautz

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Yamada, L., Kobayashi, K., Degnan, B. et al. A genomewide survey of developmentally relevant genes in Ciona intestinalis . Dev Genes Evol 213, 245–253 (2003). https://doi.org/10.1007/s00427-003-0316-x

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Keywords

  • Basal chordates
  • bZip
  • Ciona intestinalis
  • GATA/Gli/Zic/Snail
  • Genomewide survey
  • HMG transcriptional regulators