Presenilins play prominent roles in the molecular pathogenesis of Alzheimer's disease and during embryo development. We have isolated a zebrafish presenilin orthologue (pre2), which shows a high degree of sequence identity to the human PS2 protein. Zebrafish pre2 is maternally and ubiquitously expressed during early embryo development, whereas Pre2 protein expression is initiated between 6 and 12 hours post fertilisation (hpf), suggesting strict regulation of pre2 translation. pre2 expression is especially high in neural-crest-derived melanocytes.
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Groth, C., Nornes, S., McCarty, R. et al. Identification of a second presenilin gene in zebrafish with similarity to the human Alzheimer's disease gene presenilin2 . Dev Genes Evol 212, 486–490 (2002). https://doi.org/10.1007/s00427-002-0269-5
- Alzheimer's disease Presenilin Neural crest Melanocyte Zebrafish