Mitochondrial dynamics in exercise physiology

  • Tomohiro Tanaka
  • Akiyuki Nishimura
  • Kazuhiro Nishiyama
  • Takumi Goto
  • Takuro Numaga-Tomita
  • Motohiro NishidaEmail author
Invited Review
Part of the following topical collections:
  1. Invited review


A growing body of evidence suggests that exercise shows pleiotropic effects on the maintenance of systemic homeostasis through mitochondria. Dysregulation of mitochondrial dynamism is associated with metabolic inflexibility, resulting in many of the metabolic diseases and aging. Studies have suggested that exercise prevents and delays the progression of mitochondrial dysfunction by improving mitochondrial metabolism, biogenesis, and quality control. Exercise modulates functions of mitochondrial dynamics-regulating proteins through post-translational modification mechanisms. In this review, we discuss the putative mechanisms underlying maintenance of mitochondrial homeostasis by exercise, especially focusing on the post-translational modifications of several signaling proteins contributing to mitochondrial biogenesis, autophagy or mitophagy flux, and fission/fusion cycle. We also introduce novel small molecules that can potentially mimic exercise therapy through preserving mitochondrial dynamism. These recent advancements in the field of mitochondrial biology may lead to a greater understanding of exercise signaling.


Mitochondrial dynamics Quality control Metabolism Redox biology Drug design 



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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Tomohiro Tanaka
    • 1
    • 2
  • Akiyuki Nishimura
    • 1
    • 3
    • 4
    • 5
  • Kazuhiro Nishiyama
    • 5
  • Takumi Goto
    • 5
  • Takuro Numaga-Tomita
    • 1
    • 3
    • 4
  • Motohiro Nishida
    • 1
    • 2
    • 3
    • 4
    • 5
    Email author
  1. 1.Division of Cardiocirculatory Signaling, National Institute for Physiological Sciences (NIPS)National Institutes of Natural SciencesAichiJapan
  2. 2.Division of Plasma Biology, Center for Novel Science Initiatives (CNSI)National Institutes of Natural SciencesTokyoJapan
  3. 3.Cardiocirculatory Dynamism Research Group, Exploratory Research Center on Life and Living Systems (ExCELLS), National Institute for Physiological Sciences (NIPS)National Institutes of Natural SciencesAichiJapan
  4. 4.SOKENDAI (School of Life Science, The Graduate University for Advanced Studies)AichiJapan
  5. 5.Graduate School of Pharmaceutical SciencesKyushu UniversityFukuokaJapan

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