Pflügers Archiv - European Journal of Physiology

, Volume 470, Issue 11, pp 1583–1596 | Cite as

Potential therapeutic value of transient receptor potential channels in male urogenital system

  • Gamze Toktanis
  • Ecem Kaya-Sezginer
  • Didem Yilmaz-Oral
  • Serap GurEmail author
Invited Review
Part of the following topical collections:
  1. Invited Review


Transient receptor potential (TRP) channels comprise a family of cation channels implicated in a variety of cellular processes including light, mechanical or chemical stimuli, temperature, pH, or osmolarity. TRP channel proteins are a diverse family of proteins that are expressed in many tissues. We debated our recent knowledge about the expression, function, and regulation of TRP channels in the different parts of the male urogenital system in health and disease. Emerging evidence suggests that dysfunction of TRP channels significantly contributes to the pathophysiology of urogenital diseases. So far, there are many efforts underway to determine if these channels can be used as drug targets to reverse declines in male urogenital function. Furthermore, developing safe and efficacious TRP channel modulators is warranted for male urogenital disorders in a clinical setting.


Erectile dysfunction Lower urinary tract symptoms Overactive bladder Transient receptor potential channels 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Gamze Toktanis
    • 1
  • Ecem Kaya-Sezginer
    • 2
  • Didem Yilmaz-Oral
    • 2
    • 3
  • Serap Gur
    • 2
    Email author
  1. 1.Ankara Education and Research HospitalAnkaraTurkey
  2. 2.Faculty of Pharmacy, Department of Biochemistry and PharmacologyAnkara UniversityAnkaraTurkey
  3. 3.Faculty of Pharmacy, Department of PharmacologyCukurova UniversityAdanaTurkey

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