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European Journal of Applied Physiology

, Volume 119, Issue 7, pp 1663–1669 | Cite as

Prior cycling exercise does not prevent endothelial dysfunction after resistance exercise

  • Takuma MorishimaEmail author
  • Masahira Toyoda
  • Eisuke Ochi
Original Article

Abstract

Purpose

Resistance exercise impairs endothelial function acutely. Therefore, it becomes important to devise an effective strategy for preventing acute endothelial dysfunction after resistance exercise. Herein, we tested the hypothesis that resistance exercise-induced temporal endothelial dysfunction is prevented by prior cycling.

Methods

Twelve young healthy subjects completed two randomized experimental trials: (1) resistance exercise only trial (RE trial), (2) resistance exercise with prior cycling trial (C + RE trial). Following baseline brachial artery flow-mediated dilation (FMD), the subjects maintained the supine position for 45 min in the RE trial; the subjects performed a 45 min of cycling (67.0 ± 1.7% HRmax) in the C + RE trial. After 45 min of resting or cycling, the subjects performed resistance exercise (69.7 ± 4.0 kg) at the same time points. Following the resistance exercise, they were asked to rest in the supine position for 60 min. Then FMD were repeated at 10, 30 and 60 min after the resistance exercise in both trials.

Results

The increased blood flow and shear rate after resistance exercise did not differ between trials, and these changes disappeared following resting in the supine position for 60 min. There was no significant interaction in %FMD responses. Both trials caused impairment in %FMD after the resistance exercise, and statistical significance was observed at 30 and 60 min after resistance exercise in the RE trial.

Conclusion

The present study revealed that cycling for 45 min prior to resistance exercise was not sufficient to prevent the acute endothelial dysfunction after resistance exercise.

Keywords

Vascular function Resistance exercise Aerobic exercise Flow-mediated dilation 

Abbreviations

FMD

Flow-mediated dilation

NO

Nitric oxide

ET-1

Endothelin-1

1RM

One repetition maximum

RPE

Perceived exertion

HR

Heart rate

AUC

Area under the curve

ANOVA

Analysis of variance

ANCOVA

Analysis of covariance

SE

Standard error

\(\dot{\text{VO}}_2{\text{max}}\)

Maximal oxygen uptake

Notes

Acknowledgements

The authors appreciate the time and effort put in by all volunteer subjects. The authors also appreciate Dr. Jaume Padilla for his advice about data analysis.

Author contributions

TM and EO: conceptualized and designed the study; TM, MT, and EO: performed the experiments; TM: analyzed data; TM, MT, and EO: interpreted the results of experiments; TM: prepared figures and table. TM and EO: drafted the manuscript; TM, MT, and EO: edited and revised the manuscript; TM, MT, and EO: approved the final version of manuscript.

Funding

This work was supported by The Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research [Grant number 18K17834 (to T.M.), 18K10832 (to E.O.)].

Compliance with ethical standards

Conflict of interest

No conflicts of interest, financial or otherwise, are declared by the authors.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Takuma Morishima
    • 1
    Email author
  • Masahira Toyoda
    • 2
  • Eisuke Ochi
    • 1
    • 2
  1. 1.Sports Research CenterHosei UniversityTokyoJapan
  2. 2.Faculty of Bioscience and Applied ChemistryHosei UniversityTokyoJapan

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