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European Journal of Applied Physiology

, Volume 119, Issue 7, pp 1591–1598 | Cite as

Consecutive days of exercise decrease insulin response more than a single exercise session in healthy, inactive men

  • Todd Castleberry
  • Christopher Irvine
  • Sarah E. Deemer
  • Matthew F. Brisebois
  • Ryan Gordon
  • Michael D. Oldham
  • Anthony A. Duplanty
  • Vic Ben-EzraEmail author
Original Article

Abstract

Purpose

It is reported that a single bout of exercise can lower insulin responses 12–24 h post-exercise; however, the insulin responses to alternate or consecutive bouts of exercise is unknown. Thus, the purpose of this study was to examine the effect of exercise pattern on post-exercise insulin and glucose responses following a glucose challenge.

Methods

Ten male participants (n = 10, mean ± SD, Age 29.5 ± 7.7 years; BMI 25.7 ± 3.0 kg/m2) completed three exercise trials of walking for 60 min at ~ 70% of VO2max. The trials consisted of: three consecutive exercise days (3CON), three alternate exercise days (3ALT), a single bout of exercise (SB), and a no exercise control (R). Twelve to fourteen hours after the last bout of exercise or R, participants completed a 75 g oral glucose tolerance test (OGTT) and blood was collected at 30 min intervals for the measurement of glucose, insulin, and C-peptide.

Result

Calculated incremental area under the curve (iAUC) for glucose and C-peptide was not different between the four trials. Insulin iAUC decreased 34.9% for 3CON compared to R (p < 0.01).

Conclusion

Three consecutive days of walking at ~ 70% VO2max improved insulin response following an OGTT compared to no exercise. It is possible, that for healthy males, the effect of a single bout of exercise or exercise bouts separated by more than 24 h may not be enough stimulus to lower insulin responses to a glucose challenge.

Keywords

Consecutive days Exercise pattern Glucose Incremental area under the curve Insulin Single session 

Abbreviations

AUC

Area under the curve

iAUC

Incremental area under the curve

OGTT

Oral glucose tolerance test

3ALT

Three alternate days

3CON

Three consecutive days

Notes

Acknowledgment

This study was supported in part by the Texas Woman's University Office of Research and Sponsored Programs, as well as the Department of Kinesiology. SED is currently supported by a T32 Postdoctoral Award from the National Institute of Diabetes and Digestive and Kidney Diseases (T32DK062710). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIDDK or the NIH.

Author contributions

TC was responsible for collecting and analyzing data, and writing the manuscript. CI and RG were responsible for collecting data, analyzing data, and manuscript revisions. SD collected data and reviewed and edited the manuscript. MB, MO, and JR collected and analyzed data. AD reviewed data and edited manuscript. VB designed the research study, collected the data, and edited the manuscript.

Compliance with ethical standards

Conflict of interest

The authors have no conflicts of interest to declare.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of KinesiologyTexas Christian UniversityFort WorthUSA
  2. 2.Department of KinesiologyTexas Woman’s UniversityDentonUSA
  3. 3.Nutrition Obesity Research CenterUniversity of Alabama at BirminghamBirminghamUSA

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