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European Journal of Applied Physiology

, Volume 119, Issue 5, pp 1261–1272 | Cite as

The effects of aging on the distribution of cerebral blood flow with postural changes and mild hyperthermia

  • Akemi Ota
  • Ryosuke Takeda
  • Daiki Imai
  • Nooshin Naghavi
  • Eriko Kawai
  • Kosuke Saho
  • Emiko Morita
  • Yuta Suzuki
  • Hisayo Yokoyama
  • Toshiaki Miyagawa
  • Kazunobu OkazakiEmail author
Original Article
  • 84 Downloads

Abstract

Purpose

Cerebral blood flow (CBF) would be impaired with dual stresses of heat and orthostatic changes, even if those stresses are mild, in the elderly with declined cardio- and cerebrovascular functions with aging. To test the hypothesis, we compared the response of blood flow in the internal carotid artery (ICA) and vertebral artery (VA) to dual stresses of heat and orthostatic changes between the elderly and young individuals.

Methods

Nine elderly and eight young healthy men (71.3 ± 3.0 and 23.3 ± 3.1 years, mean ± SD, respectively) underwent measurements of blood flow in the ICA, VA and external carotid artery (ECA) via ultrasonography. The measurements were obtained in sitting and supine positions under normothermic (NT) and mildly hyperthermic (HT) conditions (ambient temperature 28 °C). Esophageal temperatures increased from NT (36.4 ± 0.2 °C, mean ± SE) to HT (37.4 ± 0.2 °C) with lower legs immersion in 42 °C water.

Results

With heat stress, ECA blood flow increased in both postures in both age groups (effect of heat, p < 0.001), whereas ICA blood flow remained unchanged. With postural changes from supine to sitting, ECA blood flow remained unchanged whereas ICA blood flow decreased (effect of posture, p = 0.027) by 18% in NT in the young and by 20% in HT in the elderly. VA blood flow remained unchanged under both heat stress and postural changes.

Conclusions

The CBF is impaired under dual stresses of heat and orthostatic changes in healthy aged individuals, even if the levels of the stresses are mild.

Keywords

Carotid artery Orthostatic stress Heat stress Elderly 

Abbreviations

CBF

Cerebral blood flow

ECA

External carotid artery

ICA

Internal carotid artery

VA

Vertebral artery

CO

Cardiac output

MCAv

Blood flow velocity in the middle cerebral artery

SV

Stroke volume

Tes

Esophageal temperature

HR

Heart rate

NT

Normothermia

HT

Hyperthermia

Tsk

Skin temperature

PP

Pulse pressure

MBP

Mean blood pressure

BP

Blood pressure

PETCO2

Partial pressure of end-tidal carbon dioxide

MRI

Magnetic resonance imaging

ANOVA

Analysis of variance

SD

Standard deviation

Notes

Acknowledgements

We are very grateful to the volunteers who participated in this study. We also thank Dr. Yoshihiro Yamashina and Mr. Yoshikazu Hirasawa from our laboratory for useful comments and suggestions regarding this manuscript. This study was supported in part by a Grant-in-Aid for Scientific Research (C), Grant number 17K01656 (to A. Ota), and by a Grant-in-Aid for Scientific Research (B), Grant number 17H03741 (to K. Okazaki) from Japan Society for the Promotion of Science.

Author contributions

AO contributed to the design of the experiment, data collection, assembly, analysis and interpretation, and drafted the article; RT, DI, NN, EK, KS, EM, YS, and HY contributed to data collection, analysis and interpretation, and revised the article; TM contributed to data interpretation and revised the article; KO contributed to the conception, the design of the experiment, data interpretation, and revised the article critically for important intellectual content. All authors approved the final version of the manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Akemi Ota
    • 1
    • 2
  • Ryosuke Takeda
    • 3
  • Daiki Imai
    • 1
    • 3
  • Nooshin Naghavi
    • 1
  • Eriko Kawai
    • 1
  • Kosuke Saho
    • 1
  • Emiko Morita
    • 1
  • Yuta Suzuki
    • 1
    • 3
  • Hisayo Yokoyama
    • 1
    • 3
  • Toshiaki Miyagawa
    • 1
    • 3
  • Kazunobu Okazaki
    • 1
    • 3
    Email author
  1. 1.Department of Environmental Physiology for ExerciseOsaka City University Graduate School of MedicineOsakaJapan
  2. 2.Department of Health Promotion and Sports ScienceOsaka Electro-Communication UniversityOsakaJapan
  3. 3.Research Center for Urban Health and SportsOsaka City UniversityOsakaJapan

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