The effect of blood flow occlusion during acute low-intensity isometric elbow flexion exercise
Blood flow restriction (BFR) with low-intensity (< 30% of 1 repetition maximum strength) muscle contraction has been used chronically (> 4 weeks) to enhance resistance training. However, mechanisms underlying muscle adaptations following BFR are not well understood. To explore changes related to chronic BFR adaptations, the current study used blood flow occlusion (BFO) during an acute bout of low-intensity isometric fatiguing contractions to assess peripheral (muscle) factors affected.
Ten males completed separate fatiguing elbow flexor protocols to failure; one with BFO and one with un-restricted blood flow (FF). Baseline, post-task failure, and 30 min of recovery measures of voluntary and involuntary contractile properties were compared.
BFO had greater impairment of intrinsic measures compared with FF, despite FF lasting 80% longer. Following task failure, maximal voluntary contraction and 50 Hz torque decreased in both protocols (~ 60% from baseline). Voluntary activation decreased ~ 11% from baseline at failure following both protocols, but recovered at a faster rate following BFO, whereas MVC recovered to ~ 90% of baseline in both protocols. The 10/50 Hz torque ratio was decreased by ~ 68% and ~ 21% from baseline, for BFO and FF, respectively (P < 0.01). 50 Hz half-relaxation-time (HRT) was significantly longer immediately following BFO (~ 107% greater than baseline), with no change following FF.
Thus, greater peripheral fatigue that recovers at a similar rate compared to conventional exercise is likely driving muscle adaptations observed with chronic BFR exercise. Likely BFO alters energy demand and supply of working muscle similar to chronic BFR, but is exaggerated in this paradigm.
KeywordsBlood flow restriction Elbow flexion Fatigue Intrinsic muscle properties Low-frequency fatigue Peripheral fatigue
DB Copithorne: experimental design, data collection and analysis, all manuscript revisions and edits. CL Rice: all manuscript revisions and edits.
This research was supported by the Natural Sciences and Engineering Research Council (NSERC) as well as Ontario Graduate Scholarships (OGS).
Compliance with ethical standards
Conflict of interest
DB Copithorne and CL Rice have no conflicts of interest that are directly relevant to the content of this article.
- Abe T, Sakamaki M, Fujita S, Ozaki H, Sugaya M, Sato Y, Nakajima T (2010) Effects of low-intensity walk training with restricted leg blood flow on muscle strength and aerobic capacity in older adults. J Geriatr Phys Ther 33(1):34–40Google Scholar
- Alway SE, Sale DG, MacDougall JD (1990) Twitch contractile adaptations are not dependent on the intensity of isometric exercise in the human triceps surae. Eur J Appl Physiol Occup Physiol 60(5):346–352Google Scholar
- American College of Sports Medicine (2009) American College of Sports Medicine position stand. Progression models in resistance training for healthy adults. Med Sci Sports Exerc 41(3):687Google Scholar
- Behm DG, St-Pierre DMM (1997) Effects of fatigue duration and muscle type on voluntary and evoked contractile properties. J Appl Physiol 82(5):1654–1661Google Scholar
- Behm DG, St-Pierre DMM, Perez D (1996) Muscle inactivation: assessment of interpolated twitch technique. J Appl Physiol 81(5):2267–2273Google Scholar
- Belanger AY, McComas AJ (1981) Extent of motor unit activation during effort. J Appl Physiol 51(5):1131–1135Google Scholar
- Booth J, McKenna MJ, Ruell PA, Gwinn TH, Davis GM, Thompson MW, Harmer AR, Hunter SK, Sutton JR (1997) Impaired calcium pump function does not slow relaxation in human skeletal muscle after prolonged exercise. J Appl Physiol 83(2):511–521Google Scholar
- Burd NA, West DW, Staples AW, Atherton PJ, Baker JM, Moore DR, Holwerda AM, Parise G, Rennie MJ, Baker SK, Phillips SM (2010) Low-load high volume resistance exercise stimulates muscle protein synthesis more than high-load low volume resistance exercise in young men. PLoS One 5(8):e12033Google Scholar
- Button DC, Behm DG (2008) The effect of stimulus anticipation on the interpolated twitch technique. J Sports Sci Med 7(4):520Google Scholar
- Cady EB, Elshove H, Jones DA, Moll A (1989) The metabolic causes of slow relaxation in fatigued human skeletal muscle. J Physiol 418(1):327–337Google Scholar
- Cook SB, Murphy BG, Labarbera KE (2013) Neuromuscular function after a bout of low-load blood flow-restricted exercise. Med Sci Sports Exerc 45(1):67–74Google Scholar
- Cook CJ, Kilduff LP, Beaven CM (2014) Improving strength and power in trained athletes with 3 weeks of occlusion training. Int J Sports Physiol Perform 9(1):166–172Google Scholar
- Edwards RH, Hill DK, Jones DA, Merton PA (1977) Fatigue of long duration in human skeletal muscle after exercise. J Physiol 272(3):769–778Google Scholar
- Farina D, Merletti R, Enoka RM (2004) The extraction of neural strategies from the surface EMG. J Appl Physiol 96(4):1486–1495Google Scholar
- Gandevia SC (2001) Spinal and supraspinal factors in human muscle fatigue. Physiol Rev 81(4):1725–1789Google Scholar
- Greising SM, Gransee HM, Mantilla CB, Sieck GC (2012) Systems biology of skeletal muscle: fiber type as an organizing principle. Wiley Interdiscip Rev Syst Biol Med 4(5):457–473Google Scholar
- Hill CA, Thompson MW, Ruell PA, Thom JM, White MJ (2001) Sarcoplasmic reticulum function and muscle contractile character following fatiguing exercise in humans. J Physiol 531(3):871–878Google Scholar
- Jones DA (1981) Muscle fatigue due to changes beyond the neuromuscular junction. Hum Muscle Fatigue Physiol Mech 1981(178–196)Google Scholar
- Jones DA (1996) High-and low-frequency fatigue revisited. Acta Physiol 156(3):265–270Google Scholar
- Jones DA, Bigland-Ritchie B, Edwards RHT (1979) Excitation frequency and muscle fatigue: mechanical responses during voluntary and stimulated contractions. Exp Neurol 64(2):401–413Google Scholar
- Karabulut M, Cramer JT, Abe T, Sato Y, Bemben MG (2010) Neuromuscular fatigue following low-intensity dynamic exercise with externally applied vascular restriction. J Electromyogr Kinesiol 20(3):440–447Google Scholar
- Kumar V, Selby A, Rankin D, Patel R, Atherton P, Hildebrandt W, Williams J, Smith K, Seynnes O, Hiscock N, Rennie MJ (2009) Age-related differences in the dose–response relationship of muscle protein synthesis to resistance exercise in young and old men. J Physiol 587(1):211–217Google Scholar
- Manimmanakorn A, Hamlin MJ, Ross JJ, Taylor R, Manimmanakorn N (2013a) Effects of low-load resistance training combined with blood flow restriction or hypoxia on muscle function and performance in netball athletes. J Sci Med Sport 16(4):337–342Google Scholar
- Manimmanakorn A, Manimmanakorn N, Taylor R, Draper N, Billaut F, Shearman JP, Hamlin MJ (2013b) Effects of resistance training combined with vascular occlusion or hypoxia on neuromuscular function in athletes. Eur J Appl Physiol 113(7):1767–1774Google Scholar
- Moritani T, Sherman WM, Shibata M, Matsumoto T, Shinohara M (1992) Oxygen availability and motor unit activity in humans. Eur J Appl Physiol Occup Physiol 64(6):552–556Google Scholar
- Ohta H, Kurosawa H, Ikeda H, Iwase Y, Satou N, Nakamura S (2003) Low-load resistance muscular training with moderate restriction of blood flow after anterior cruciate ligament reconstruction. Acta Orthop Scand 74(1):62–68Google Scholar
- Ozaki H, Miyachi M, Nakajima T, Abe T (2011) Effects of 10 weeks walk training with leg blood flow reduction on carotid arterial compliance and muscle size in the elderly adults. Angiology 62(1):81–86Google Scholar
- Ratamess NA, Alvar BA, Evetoch TK (2009) Progression models in resistance training for healthy adults. American college of sports medicine. Med Sci Sports Exerc 41(3):687–708Google Scholar
- Scott BR, Loenneke JP, Slattery KM, Dascombe BJ (2015) Exercise with blood flow restriction: an updated evidence-based approach for enhanced muscular development. Sports Med 45(3):313–325Google Scholar
- Verges S, Maffiuletti NA, Kerherve H, Decorte N, Wuyam B, Millet GY (2009) Comparison of electrical and magnetic stimulations to assess quadriceps muscle function. J Appl Physiol 106(2):701–710Google Scholar
- Yasuda T, Brechue WF, Fujita T, Sato Y, Abe T (2008) Muscle activation during low-intensity muscle contractions with varying levels of external limb compression. J Sports Sci Med 7(4):467Google Scholar
- Yasuda T, Brechue WF, Fujita T, Shirakawa J, Sato Y, Abe T (2009) Muscle activation during low-intensity muscle contractions with restricted blood flow. J Sports Sci 27(5):479–489Google Scholar
- Yasuda T, Ogasawara R, Sakamaki M, Bemben MG, Abe T (2011) Relationship between limb and trunk muscle hypertrophy following high-intensity resistance training and blood flow–restricted low-intensity resistance training. Clin Physiol Funct Imaging 31(5):347–351Google Scholar