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Predicting the ergogenic response to methylphenidate

Abstract

Purpose

Methylphenidate (MPH) and other stimulants have been shown to enhance physical performance. However, stimulant research has almost exclusively been conducted in young, active persons with a normal BMI, and may not generalize to other groups. The purpose of this study was to determine whether the ergogenic response to MPH could be predicted by individual level characteristics.

Methods

We investigated whether weekly minutes of moderate-to-vigorous physical activity (MVPA), age, and BMI could predict the ergogenic response to MPH. In a double-blind, cross-over design 29 subjects (14M, 15F, 29.7 ± 9.68 years, BMI: 26.1 ± 6.82, MVPA: 568.8 ± 705.6 min) ingested MPH or placebo before performing a handgrip task. Percent change in mean force between placebo and MPH conditions was used to evaluate the extent of the ergogenic response.

Results

Mean force was significantly higher in MPH conditions [6.39% increase, T(25) = 3.09, p = 0.005 118.8 ± 37.96 (± SD) vs. 111.8 ± 34.99 Ns] but variable (coefficient of variation:163%). Using linear regression, we observed that min MVPA (T(25) = −2.15, β = −0.400, p = 0.044) and age [T(25) = −3.29, β = −0.598, p = 0.003] but not BMI [T(25) = 1.67, β = 0.320 p = 0.109] significantly predicted percent change in mean force in MPH conditions.

Conclusions

We report that lower levels of physical activity and younger age predict an improved ergogenic response to MPH and that this may be explained by differences in dopaminergic function. This study illustrates that the ergogenic response to MPH is partly dependent on individual differences such as habitual levels of physical activity and age.

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Author information

The roles of the authors were as follows: MK: conception, data acquisition, design, interpretation, and drafting, KVB: data acquisition and drafting, DS: interpretation and drafting, KL: analysis, interpretation, and drafting, and HGLR: interpretation and drafting.

Correspondence to Michael King.

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Conflict of interest

Novartis did not influence study design, data collection, analysis, interpretation, writing, or decision to submit the article for publication. No authors were paid by Novartis.

Additional information

Communicated by Nicolas Place.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary Digital Content 1. Custom-built mock-fMRI used during familiarization session (TIF 4585 KB)

Supplementary Digital Content 2. Participants performed 40 grip trials in the power grip position by flexing all digits around a custom-made MRI-compatible isometric handgrip dynamometer. Each grip trial was composed of alternating grip and rest periods, which lasted 12–13 and 5–7 s, respectively. The entire task lasted 13 min and 20 s. A grip trial was defined as failed if a participants’ force dropped below the target force by more than 10 % after having reached the target force (TIF 4525 KB)

Supplementary material 3 (MP4 10970 KB)

Supplementary material 3 (MP4 10970 KB)

Supplementary Digital Content 3. Z score distributions of percent improvement (A), BMI (B), age (C), and min MVPA (D). The outlier value excluded from analyses is indicated in red (PDF 117 KB)

Supplementary material 5 (XLSX 38 KB)

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Cite this article

King, M., Van Breda, K., Stein, D.J. et al. Predicting the ergogenic response to methylphenidate. Eur J Appl Physiol 118, 777–784 (2018). https://doi.org/10.1007/s00421-018-3800-8

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Keywords

  • Ergogenic stimulants
  • Athletic performance
  • Athletic doping
  • Ritalin