Effects of commodity on the risk of emphysema in South African miners
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To examine associations between mine commodity such as coal, platinum, or diamonds and emphysema among South African miners at autopsy.
We examined the association between mine commodity and emphysema using the Pathology Automation (PATHAUT) database, 1975–2014. Exposure was characterized as longest tenure in each commodity. We constructed separate multivariable logistic regression models for black and white miners. Smoking was assessed in a sub-analysis of white miners.
Among black miners, coal mining was significantly associated with increased odds of emphysema [OR = 2.39 (95% CI 1.86, 3.07)] when compared to gold mining. Asbestos was also associated with significantly increased odds of emphysema among black miners [OR = 1.47 (95% CI 1.01, 2.12)]. No associations between commodity and emphysema were observed among white miners. Cumulative years of exposure and age at death were significant predictors for emphysema for both black and white miners. Smoking was a significant predictor of emphysema in the sub-analysis of white miners with smoking information, but no effect of commodity was observed.
We observed a significant association between coal mining and emphysema among black miners. Adverse health effects of coal mining are evidenced by more than twofold increase in emphysema among black coal miners compared to gold miners. This suggests that South African Coal miners are exposed to high dust concentrations or more damaging components compared to other commodities, resulting in elevated risk of emphysema.
KeywordsEmphysema Mining Occupation Commodity South Africa PATHAUT
The research and researchers were supported in part by the National Institute of Occupational Safety and Health (NIOSH) Training Program Grant # T42/OH008672.
Conflict of interest
All authors have declared that they have no conflicts of interest that may be relevant to the submitted work.
- Chakrabarti B, Calverley PM, Davies PD (2007) Tuberculosis and its incidence, special nature, and relationship with chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 2:263–272Google Scholar
- Chamber of Mines SA (2017) Mining in SA—Chamber of Mines South Africa. http://www.chamberofmines.org.za/sa-mining. Accessed 13 Mar 2017
- Churg A, Zay K, Li K (1997) Mechanisms of mineral dust-induced emphysema. Environ Health Perspect 105:1215–1218Google Scholar
- Human Sciences Research Council (2011) South Africa Mining Sector Employment Forecast to 2025. http://docplayer.net/21149758-South-african-mining-sector-employment-forecast-to-2025.html. Accessed 16 Nov 2016
- Kgokong N, Vorajee N, Lakhoo D et al (2018) Pathology division surveillance report: demographic data and disease rates for January to December 2017. http://www.nioh.ac.za/publications/pathology-disease-surveillance-reports/. Accessed 27 May 2019
- Murray J, Sonnenberg P, Nelson G et al (2007) Cause of death and presence of respiratory disease at autopsy in an HIV-1 seroconversion cohort of southern African gold miners. AIDS 21(Suppl 6):S97–S104. https://doi.org/10.1097/01.aids.0000299416.61808.24 CrossRefGoogle Scholar
- Osinubi OY, Gochfeld M, Kipen HM (2000) Health effects of asbestos and nonasbestos fibers. Environ Health Perspect 108:665–674Google Scholar
- RSA (1973) Occupational disease in mines and works act. Government Printer, PretoriaGoogle Scholar
- Stanton D, Belle B, Dekker K, Plessis J (2006) Mining industry best practice on the prevention of silicosis. Mine Health and Safety Council, BraamfonteinGoogle Scholar
- UNAIDS (2006) 2006 Report on the global AIDS epidemic. A UNAIDS 10 anniversary special edition. http://data.unaids.org/pub/report/2006/2006_gr_en.pdf. Accessed 28 Jan 2019
- van Walbeek C (2002) Recent trends in smoking prevalence in South Africa—some evidence from AMPS data. S Afr Med J 92:468–472Google Scholar
- Walton WH, Dodgson J, Hadden GG, Jacobsen M (1975) The effect of quartz and other non-coal dusts in coal workers’ pneumoconiosis Part I: Epidemiological studies. Inhaled Part 4(Pt 2):669–690Google Scholar
- Zay K, Loo S, Xie C et al (1999) Role of neutrophils and alpha1-antitrypsin in coal- and silica-induced connective tissue breakdown. Am J Physiol 276:L269–L279Google Scholar