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Risk of mesothelioma after cessation of asbestos exposure: a systematic review and meta-regression

  • Paolo BoffettaEmail author
  • Francesca Donato
  • Enrico Pira
  • Hung N. Luu
  • Carlo La Vecchia
Original Article

Abstract

Purpose

A ‘risk reversal’ has been observed for several human carcinogens following cessation of exposure, but it is unclear whether it also exists for asbestos-related mesothelioma.

Methods

We conducted a systematic review of the literature and identified nine studies that reported information on risk of mesothelioma after cessation of asbestos exposure, and performed a meta-regression based on random effects models. As comparison we analyzed results on lung cancer risk from four of these studies.

Results

A total of six risk estimates from five studies were included in the meta-analysis. The summary relative risk (RR) of mesothelioma for 10-year interval since cessation of exposure was 1.02 [95% confidence interval (CI) 0.87–1.19; p-heterogeneity 0.01]. The corresponding RR of lung cancer was 0.91 (95% CI 0.84–0.98).

Conclusions

This analysis provides evidence that the risk of mesothelioma does not decrease after cessation of asbestos exposure, while lung cancer risk does.

Keywords

Asbestos Mesothelioma Time since last exposure 

Notes

Acknowledgements

The authors thank C. Pelucchi from the University of Milan, who produced original results for the study of Italian asbestos miners (Pira et al. 2017).

Compliance with ethical standards

Conflict of interest

PB, EP and CLV acted as experts for the defense (PB, EP, CLCV) and the court (EP, CLV) in asbestos-related litigation.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.The Tisch Cancer Institute, Icahn School of Medicine at Mount SinaiNew YorkUSA
  2. 2.Department of Medical and Surgical SciencesUniversity of BolognaBolognaItaly
  3. 3.Department of Public Health and Pediatric SciencesUniversity of TurinTurinItaly
  4. 4.Division of Cancer Control and Population Sciences, UPMC Hillman Cancer CenterUniversity of PittsburghPittsburghUSA
  5. 5.Department of Epidemiology, Graduate School of Public HealthUniversity of PittsburghPittsburghUSA
  6. 6.Department of Clinical Sciences and Community HealthUniversity of MilanMilanItaly

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