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Evaluation of choroidal thickness and choroidal vascular blood flow in patients with thyroid-associated orbitopathy (TAO) using SD-OCT and Angio-OCT

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Abstract

Purpose

The aim of this study was to evaluate changes in choroidal thickness and in choroidal vascular blood flow in patients with thyroid-associated orbitopathy (TAO) and their relationship with clinical features and disease activity using spectral domain optical coherence tomography (SD-OCT) and Angio-OCT technology.

Methods

Eighteen patients and control subjects underwent a complete eye examination, OCT, and Angio-OCT. We also obtained angiographic scans at 3 different consecutive levels (L1, L2, and L3) below the choriocapillary.

Results

The subfoveal choroid was significantly thicker in TAO patients than the control eyes (285.6275 ± 32.5 μm compared with 135.89 ± 19.8 μm, respectively, p = 0.0089). The correlation analysis in the TAO group showed a significant correlation between the choroidal thickness and EUGOGO clinical score (r = 0.84, p = 8.44032E-07). Vascular flow of choriocapillary was markedly reduced in subjects with TAO compared with healthy subjects (49.78 ± 4.5 vs. 53.36 ± 1.07; p = 2.5105E-07) and vascular flow of the deeper layer L3 resulted higher in subjects with TAO than in healthy subjects (46.9 ± 20.23 and 41.475 ± 3.06; p = 0.01168).

Conclusions

Subfoveal choroidal thickness and choroidal blood flow were significantly different in patients with TAO compared with healthy subjects.

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References

  1. 1.

    Bahn RS (2010) Graves’ ophthalmopathy. N Engl J Med 362(8):726–738

  2. 2.

    Bartley GB (1994) The epidemiologic characteristics and clinical course of ophthalmopathy associated with autoimmune thyroid disease in Olmstead County, Minnesota. Trans Am Ophthalmol Soc 92:477–588

  3. 3.

    Çalışkan S, Acar M, Gürdal C (2017) Choroidal thickness in patients with Graves’ ophthalmopathy. Curr Eye Res 42(3):484–490

  4. 4.

    Özkan B, Koçer ÇA, Altintaş Ö, Karabaş L, Acar AZ, Yüksel N (2016) Choroidal changes observed with enhanced depth imaging optical coherence tomography in patients with mild graves orbitopathy. Eye 30(7):917–924

  5. 5.

    Margolis R, Spaide RF (2009) A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes. Am J Ophthalmol 147(5):811–815

  6. 6.

    Nickla DL, Wallman J (2010) The multifunctional choroid. Prog Retin Eye Res 29(2):144–168

  7. 7.

    Nicolo’ M, Rosa R, Musetti D, Musolino M, Saccheggiani M, Traverso CE (2017) Choroidal vascular flow area in central serous chorioretinopathy using swept-source optical coherence tomography angiography. Invest Ophthalmol Vis Sci 58:2002–2010. https://doi.org/10.1167/iovs.17-21417

  8. 8.

    Nakase Y, Osanai T, Yoshikawa K, Inoue Y (1994) Color Doppler imaging of orbital venous flow in dysthyroid optic neuropathy. Jpn J Ophthalmol 38:80–86

  9. 9.

    Otto AJ, Koornneef L, Mourits MP, Deen-van LL (1996) Retrobulbar pressures measured during surgical decompression of the orbit. Br J Ophthalmol 80:1042–1045

  10. 10.

    Somer D, Ozkan SB, Ozdemir H, Atilla S, Söylev MF, Duman S (2002) Colour Doppler imaging of superior ophthalmic vein in thyroid associated eye disease. Jpn J Ophthalmol 46:341–345

  11. 11.

    Odrobina D, Laudanska-Olszewska I, Gozdek P, Maroszynski M, Amon M (2013) Influence of scleral buckling surgery with encircling band on subfoveal choroidal thickness in long-term observations. Biomed Res Int 2013:586–894

  12. 12.

    Yu N, Zhang Y, Kang L, Gao Y, Zhang J, Wu Y (2018) Analysis in choroidal thickness in patients with Graves’ ophthalmopathy using spectral-domain optical coherence tomography. J Ophthalmol 2018:3529395

  13. 13.

    Barrio-Barrio J, Sabater A, Bonet-Farriol E, Velázquez-Villoria Á, Galofré JC (2017) Graves’ Ophthalmopathy: VISA versus EUGOGO Classification, Assessment, and Management. J Ophthalmol 2015:249125

  14. 14.

    Yanik B, Conkbayir I, Acaroglu G, Hekimoglu B (2005) Graves’ ophthalmopathy: comparison of the Doppler sonography parameters with the clinical activity score. J Clin Ultrasound 33(8):375–380

  15. 15.

    Tranquart F, Bergès O, Koskas P et al (2003) Color Doppler imaging of orbital vessels: personal experience and literature review. J Clin Ultrasound 31(5):258–273

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Author information

Conception and design: Del Noce, Vagge. Acquisition of data: Del Noce. Analysis and interpretation of data: Del Noce, Vagge, Iester, Nicolò. Drafting the article: Del Noce, Vagge. Critically revising the article: Traverso, Iester. Reviewed the submitted version of manuscript: Del Noce, Vagge, Nicolò, Traverso. Approved the final version of the manuscript on behalf of all authors: Del Noce, Vagge. Statistical analysis: Del Noce, Traverso, Iester. Study supervision: Vagge, Traverso.

Correspondence to Aldo Vagge.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional review board and with the Helsinki declaration and its later amendments or comparable ethical standards.

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The participants provided informed consent. Patient information was anonymized and de-identified prior to analysis.

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Del Noce, C., Vagge, A., Nicolò, M. et al. Evaluation of choroidal thickness and choroidal vascular blood flow in patients with thyroid-associated orbitopathy (TAO) using SD-OCT and Angio-OCT. Graefes Arch Clin Exp Ophthalmol (2020). https://doi.org/10.1007/s00417-020-04616-9

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Keywords

  • Angio-OCT
  • Choroid
  • OCT
  • Orbitopathy
  • Thyroid