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Clinical and visual outcome of endophthalmitis patients: a single-center experience

  • Marcel KitscheEmail author
  • Robert Herber
  • Lutz E. Pillunat
  • Naim Terai
Inflammatory Disorders
  • 40 Downloads

Abstract

Purpose

To report the clinical and visual outcome and the therapeutical management in a large cohort of endophthalmitis patients.

Methods

In a monocentric, observational study, we retrospectively analyzed the data of all patients with endophthalmitis who were referred to the department of ophthalmology of the Carl Gustav Carus Hospital Dresden between 2006 and 2018.

Results

In total, data of 104 patients (49 female, 55 male) were included in the present analysis. The most frequent clinical scenario for endophthalmitis was postcataract surgery (30.8%). The most frequent treatment at presentation was a pars plana vitrectomy (ppV) in 42 patients, followed by an intravitreal antibiotic in 41 patients. Out of 41 patients who received an intravitreal antibiotic, 35 patients (85%) needed additional treatment. In contrast, out of 42 patients who received a ppV as the initial treatment, 19 patients (42%) needed additional therapy, which was significantly different (p < 0.0001). The best presenting visual acuity improved significantly after treatment (p < 0.0001).

Conclusion

The results of the present study suggest that, compared with an intravitreal antibiotic, a ppV as the initial therapy of endophthalmitis might reduce the number of additional treatments. From our data, it can be hypothesized that a ppV should be performed as early as possible to achieve the best visual outcome in most endophthalmitis patients. Prospective studies are now needed to address this issue in greater detail and to confirm our findings.

Keywords

Endophthalmitis Phacoemulsification Intravitreal injection Antibiotics Pars plana vitrectomy 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study (retrospectively study), formal consent is not required. This article does not contain any studies with human participants or animals performed by any of the authors.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of OphthalmologyCarl Gustav Carus University Hospital DresdenDresdenGermany

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