Clinical and etiologic characteristics of de novo uveitis in patients aged 60 years and above: experience of a French tertiary center

  • P. Grumet
  • S. Kerever
  • T. Gilbert
  • L. Kodjikian
  • M. Gerfaud-Valentin
  • A. De Parisot
  • Y. Jamilloux
  • P. SèveEmail author
Inflammatory Disorders



To describe the characteristics of de novo uveitis in patients ≥ 60 years old.


Retrospective review of patients with uveitis followed in our tertiary center over a 14-year period. Patients aged 60–70 years and patients aged > 70 years were compared.


A total of 283/1044 (27.1%) patients with uveitis were ≥ 60 years of age. Idiopathic uveitis (36.1%) and sarcoidosis (31.5%) were the most frequent etiologies. Sarcoidosis was significantly more frequent (31.5% vs. 13.7%, p < 0.0001) after the age of 60 years. Intraocular lymphoma (5.0% vs. 1.1%) and herpes virus infection (5.0% vs. 0.9%) were also more common in this age group, unlike HLA B27-related uveitis and spondyloarthritis (4.6% vs. 14.9%). Pure ophthalmologic entities: birdshot retinochoroidopathy (2.8%) or Fuchs uveitis (0.4%), were rare in patients ≥ 60 years of age and Posner Scholssman, Pars planitis, White dots syndrome, Behçet’s disease, and Multiple Sclerosis were never reported. In patients > 70 years old, idiopathic uveitis (41.1% vs. 31.7%) and presumed sarcoidosis (56.5% vs. 25.6%) were more frequent than in the 60–70-year age group.


In our center, sarcoidosis is the leading cause of non-idiopathic uveitis in older patients. Idiopathic uveitis and other entities account for less than two-thirds of cases. Ophthalmologic entities are rare after 60 years of age. We also report for the first time the characteristics of uveitis after 70 years of age.


Diagnosis Epidemiology Etiology Older patients Sarcoidosis Uveitis 


Compliance with ethical standards

Conflict of interest

P. Grumet declares that he has no conflict of interest.

S. Kerever declares that he has no conflict of interest.

T. Gilbert declares that he has no conflict of interest.

L. Kodjikian has received speaker honorarium from ABBVIE, ALLERGAN, BAYER, NOVARTIS, ROCHE, and THEA.

M. Gerfaud-Valentin has received a speaker honorarium from SOBI.

A. De Parisot declares that she has no conflict of interest.

Y. Jamilloux has received a speaker honorarium from SOBI.

P. Sève has received speaker honorarium from ABBVIE, AKCEA THERAPEUTICS, GSK, NOVARTIS, SOBI, and ROCHE; he is a member of committee PEPITE (NOVARTIS).

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Ethical approval

This article does not contain any studies with animals performed by any of the authors.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Supplementary material

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • P. Grumet
    • 1
  • S. Kerever
    • 2
  • T. Gilbert
    • 3
  • L. Kodjikian
    • 4
  • M. Gerfaud-Valentin
    • 1
  • A. De Parisot
    • 1
  • Y. Jamilloux
    • 1
  • P. Sève
    • 1
    • 5
    • 6
    Email author
  1. 1.Servicede Médecine Interne, Hôpital de la Croix-Rousse, Hospic es Civils de LyonUniversité Claude Bernard-Lyon 1Lyon Cedex 04France
  2. 2.Service d’Anesthésie-RéanimationHôpital Lariboisière, Assistance Publique-Hôpitaux de ParisParisFrance
  3. 3.Service de Gériatrie, Centre Hospitalier Lyon-Sud, Hospices Civils de LyonUniversité Claude Bernard-Lyon 1LyonFrance
  4. 4.Service d’Ophtalmologie, Hôpital de la Croix-Rousse, Hospices Civils de LyonUniversité Claude Bernard-Lyon 1LyonFrance
  5. 5.Hospices Civils de LyonPôle IMERLyonFrance
  6. 6.Univ. Lyon, University Claude Bernard Lyon 1LyonFrance

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