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Correlation between metamorphopsia and disorganization of the retinal inner layers in eyes with diabetic macular edema

  • Eri Nakano
  • Toru Ota
  • Yoko Jingami
  • Isao Nakata
  • Hisako Hayashi
  • Kenji YamashiroEmail author
Retinal Disorders

Abstract

Purpose

To investigate factors associated with the severity of metamorphopsia secondary to diabetic macular edema (ME) by evaluating optical coherence tomography (OCT) parameters including disorganization of the retinal inner layers (DRIL).

Methods

We retrospectively reviewed medical records of 37 eyes of 37 consecutive patients with diabetic ME or resolved diabetic ME, who underwent spectral-domain OCT examination and metamorphopsia assessment with M-CHARTS on the same day between November 2017 and March 2018. Age, sex, visual acuity, lens status, treatment history, and factors analyzed on OCT examination including DRIL length were evaluated in association with M-CHARTS scores.

Results

Metamorphopsia was detected in 20 eyes (54%). The patients with metamorphopsia were relatively older than those without it (P = 0.060), and DRIL length was relatively longer in eyes with metamorphopsia (P = 0.065), while visual acuity was significantly better in eyes without metamorphopsia (P = 0.048). In correlation analyses to the severity of metamorphopsia, the DRIL length was the only OCT parameter associated with the M-CHARTS score (P = 0.035), while age, visual acuity, and ME were not significantly associated with the severity of metamorphopsia (P = 0.051, 0.060, and 0.344, respectively).

Conclusion

The DRIL length was significantly associated with the severity of metamorphopsia secondary to diabetic ME. The inner retinal layer plays a key role in the development of metamorphopsia in eyes with diabetic ME. Metamorphopsia should be carefully considered when treating diabetic ME since its severity has been found to be independent of visual acuity and ME status.

Keywords

Diabetic macular edema Metamorphopsia Visual acuity Spectral-domain optical coherence tomography Disorganization of the retinal inner layers 

Notes

Compliance with ethical standards

Conflict of interest

Eri Nakano declares that she has no conflict of interest. Toru Ota declares that he has no conflict of interest. Yoko Jingami declares that she has no conflict of interest. Isao Nakata declares that he has no conflict of interest. Hisako Hayashi declares that she has no conflict of interest. Kenji Yamashiro declares that he has no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional review board of Otsu Red Cross Hospital and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was not obtained from the participants included in the study according to the opt-out policy without informed consent for retrospective studies by institutional review board of Otsu Red Cross Hospital.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of OphthalmologyOtsu Red Cross HospitalOtsuJapan

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