Ophthalmologic health status of an aging population—data from the Berlin Aging Study II (BASE-II)
- 25 Downloads
Vision of the elderly may be affected by typical age-related diseases like cataract and macular degeneration. Little is known about the effect of aging on visual difficulties and vision-related quality of life. This study was conducted to compare the ophthalmological health status of younger and older individuals within a large cohort study of residents of a greater metropolitan area (Berlin Aging Study II [BASE-II]).
A total of 1655 participants (805 men) aged 60 years and older and 494 participants (232 men) aged between 22 and 48 years from the Berlin Aging Study II were included in the analysis. The subjects were examined during a 2-day clinical examination period. History of ocular diseases, vision-related quality of life using the visual function questionnaire (VFQ- 25), refraction, distance and near visual acuity, tonometry, and color vision were provided.
Older subjects performed significantly worse concerning distance and near visual acuity, color vision, and vision-related quality of life compared to young subjects. Intraocular pressure showed no significant difference between groups. Individuals are often unaware of existing eye diseases.
The prevalence of ocular diseases and the impairment of vision increases with age. Although 98% of elderly subjects have reported to suffer from any ocular disease, subjective quality of life seems to be affected to a lesser extent.
KeywordsBASE-II Vision-related quality of life Cross-sectional Age-related ophthalmological health
The BASE-II research project is supported by the German Federal Ministry of Education and Research (Bundesministerium für Bildung und Forschung, BMBF) and the Max Planck Institute for Human Development (MPIHD), Berlin.
Compliance with ethical standards
Conflict of interest
Richard Bergholz has received a travel grant by Allergan.
Ralf Michael Dutescu has received speaker’s honoraria for presentations by Ursapharm und Horus Pharma.
Elisabeth Steinhagen-Thiessen has received honoraria for presentations, advisory board activities, or data monitoring committee activities by Abbott, Aegerion, Amgen, Astra-Zeneca, Boehringer-Ingelheim, Bristol-Myers Squibb, Fresenius, Genzyme, Kaneka, Merck Sharp & Dohme, Novartis, Roche.
Adrian Rosada has received speakers’ honoraria for presentations and advisory board activities by Fresenius and B. Braun.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
All participants gave written informed consent and the Ethics Committee of the Charité – Universitätsmedizin Berlin approved the study (approval number EA2/029/09).
- 3.Velhagen K (1964) Tafeln zur Prüfung des Farbensinns, 23rd edn. Thieme Verlag, StuttgartGoogle Scholar
- 4.Lustig SP, Cappelleri JC, Chisholm JA, Getter CA, Pleil AM, Reichel MB (2004) Validity and reliability of the German version of the 25–item National Eye Institute visual function questionnaire in patients with age–related macular degeneration. Invest OphthalmolVisSci 45:1373Google Scholar
- 5.On-line Document: R development Core team (2016)R: a language and environment for statistical computing. Version 32.5. https://www.r-project.org. Accessed 1 Jan 2018
- 11.Wang Q, Klein BE, Klein R, Moss SE (1994) Refractive status in the Beaver Dam Eye study. Invest OphthalmolVisSci 35:4344–4347Google Scholar
- 14.Lee KE, Klein BE, Klein R, Wong TY (2002) Changes in refraction over 10 years in an adult population: the Beaver Dam Eye study. Invest OphthalmolVisSci 43:2566–2571Google Scholar
- 18.Klein BE, Klein R, Linton KL (1992) Intraocular pressure in an American community. The Beaver Dam Eye study. Invest OphthalmolVisSci 33:2224–2228Google Scholar
- 24.Leibowitz HM, Krueger DE, Maunder LR, Milton RC, Kini MM, Kahn HA et al (1980) The Framingham Eye Study monograph: an ophthalmological and epidemiological study of cataract, glaucoma, diabetic retinopathy, macular degeneration, and visual acuity in a general population of 2631 adults, 1973–1975. Surv.Ophthalmol 24:335–610CrossRefGoogle Scholar
- 25.Rubin GS, West SK, Munoz B, Bandeen-Roche K, Zeger S, Schein O et al (1997) A comprehensive assessment of visual impairment in a population of older Americans. The SEE study. Salisbury eye evaluation project. Invest OphthalmolVisSci 38:557–568Google Scholar
- 33.Dandona R, Dandona L, Naduvilath TJ, Nanda A, McCarty CA (1997) Design of a population-based study of visual impairment in India: the Andhra Pradesh eye disease study. Indian JOphthalmol 45:251–257Google Scholar
- 34.Chirambo MC, Tielsch JM, West KP Jr, Katz J, Tizazu T, Schwab L et al (1986) Blindness and visual impairment in southern Malawi. Bull World Health Organ 64:567–572Google Scholar