ADenoVirus Initiative Study in Epidemiology (ADVISE)—results of a multicenter epidemiology study in Germany

  • Ludwig M. HeindlEmail author
  • Albert J. Augustin
  • Elisabeth M. Messmer
  • ADVISE study group
Letter to the Editor

Dear Editor,

Adenoviral conjunctivitis (AVC) represents a common, contagious form of conjunctivitis that may lead to persistent morbidity including vision-threatening subepithelial corneal scars and dry-eye-disease [1, 2, 3, 4, 5, 6]. Signs and symptoms can last up to 3 weeks, and patients have to be quarantined under strict hygiene instructions to prevent spread of the disease [4]. Adenovirus shedding may last up to 14 days after the beginning of signs and symptoms with marked reduction after 1 week [7, 8]. Hence, it is crucial to identify AVC patients as early as possible [1, 2, 4, 9, 10]. However, for physicians it can be sometimes challenging to diagnose AVC based on clinical signs only [2, 9, 10]. Polymerase chain reaction (PCR) and cell culture are not used routinely, since these expensive techniques are not available in all offices and are not providing prompt results. AdenoPlus® is a rapid antigen-based immunoassay detecting the presence of adenovirus at the point of care...



ADVISE study group

Katharina Bayerl-Löhe, Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany

Daniel Böhringer, Eye center, University Hospital Freiburg, Freiburg, Germany

Daniela Goos, Eye center, University Hospital Freiburg, Freiburg, Germany

Silvia Herb, Department of Ophthalmology, Staedtisches Klinikum Karlsruhe, Karlsruhe, Germany

Konrad R. Koch, Department of Ophthalmology, University of Cologne, Cologne, Germany

Stefan Koinzer, Department of Ophthalmology, University of Kiel, Kiel, Germany

Ines M. Lanzl, Department of Ophthalmology, Technical University of Munich, Munich, Germany

Katrin Lorenz, Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany

Kristina Rist, Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany

Thomas Reinhard, Eye center, University Hospital Freiburg, Freiburg, Germany

Heike Scheer-Baumann, Department of Ophthalmology, Staedtisches Klinikum Karlsruhe, Karlsruhe, Germany

Compliance with ethical standards


Supported by VISUfarma, Netherlands. The sponsor participated in the design and conduct of the study, data collection; management, analysis, and interpretation of the data; and preparation and review of the manuscript.

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Ludwig M. Heindl
    • 1
    Email author
  • Albert J. Augustin
    • 2
  • Elisabeth M. Messmer
    • 3
  • ADVISE study group
  1. 1.Department of OphthalmologyUniversity of CologneCologneGermany
  2. 2.Department of OphthalmologyStaedtisches Klinikum KarlsruheKarlsruheGermany
  3. 3.Department of OphthalmologyLudwig-Maximilians-UniversityMunichGermany

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