Vessel density, retinal thickness, and choriocapillaris vascular flow in myopic eyes on OCT angiography

  • Paolo MilaniEmail author
  • Giovanni Montesano
  • Luca Rossetti
  • Fulvio Bergamini
  • Alfredo Pece
Retinal Disorders



To investigate foveal avascular zone area, macular vascular density, choroidal thickness, and outer retina and choriocapillaris flow in myopic eyes by OCT angiography.


Automated macular maps and flow calculations were retrospectively evaluated in 42 myopic and in 40 control eyes.


Myopic eyes presented lower whole superficial vessel density (46.4 ± 4.9 vs. 51.6 ± 3.6%, P < 0.0001) and higher flow area in the outer retina (1.3 ± 0.2 vs. 1.1 ± 0.3 mm2, P = 0.0012). Between the myopic and non-myopic eyes, no significant differences could be detected in the choriocapillaris perfusion area (1.9 ± 0.07 vs. 1.9 ± 0.05 mm2, respectively; P = 0.55) and in the foveal avascular zone area (0.23 ± 0.1 vs. 0.26 ± 0.1 mm2, respectively; P = 0.12). The spherical correction positively correlated with superficial vessel density and negatively correlated with outer retina perfusion (P ≤ 0.0021). The superficial vessel density and the local retinal thickness positively correlated at all macular locations (P < 0.005), especially in the foveal region (P < 0.0001).


Eyes with high myopia present reduced superficial vascular density and increased outer retina flow. Superficial vascular density and retinal thickness appear to be significantly correlated.


OCT angiography Myopia Choriocapillaris Vessel density Outer retina 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Paolo Milani
    • 1
    Email author
  • Giovanni Montesano
    • 2
    • 3
  • Luca Rossetti
    • 2
  • Fulvio Bergamini
    • 4
  • Alfredo Pece
    • 5
  1. 1.Istituto Auxologico Italiano and Retina 3000 Eye CenterMilanItaly
  2. 2.University of Milan-ASST Santi Paolo e CarloMilanItaly
  3. 3.City, University of London, Optometry and Visual SciencesLondonUK
  4. 4.Istituto Auxologico ItalianoMilanItaly
  5. 5.Melegnano Hospital and Retina 3000 Eye CenterMilanItaly

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