Past and prognosis of anti-VEGF therapy for wet age-related macular degeneration—the future has begun

  • Justus G. GarwegEmail author
  • J. J. Zirpel
  • C. Gerhardt
  • Isabel B. Pfister
Letter to the Editor

Dear Editor,

We would like to thank Dan and Mihai Călugăru for their critical interest in our recently published work [1]. This gives us the opportunity to address the remarkable improvements that have been achieved by adopting ideal world outcomes in the therapy of exudative or wet age-related macular degeneration (AMD) using ranibizumab to the real world possibilities.

Ranibizumab was the first drug approved for the prevention of vision loss in wet AMD in 2006. The ophthalmological community believed that now a bright future had begun. Indeed, its approval revolutionized ophthalmology and opened the treatment floor for a group of vascular diseases affecting the macula that had been perceived widely untreatable by then. As we have meanwhile learned, beneficial anti-VEGF effects reach not only the macula, but eventually the entire retina [2].

Marina [3] and Anchor [4] were the first studies to show that severe vision loss and legal blindness were not any more an inevitable consequence...


Compliance with ethical standards

Conflict of interest

JGG acts as an advisor to diverse pharmaceutical companies and contributes to several clinical studies. Nevertheless, none of the authors have received direct or indirect financial support for this study or have a conflicting interest with the data that are presented in the report.

For this type of study formal consent is not required.

This article does not contain any studies with human participants or animals performed by any of the authors.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Justus G. Garweg
    • 1
    • 2
    Email author
  • J. J. Zirpel
    • 2
  • C. Gerhardt
    • 1
    • 2
  • Isabel B. Pfister
    • 1
    • 2
  1. 1.Swiss Eye Institute, Rotkreuz, and Berner Augenklinik am LindenhofspitalRotkreuzSwitzerland
  2. 2.University of BernBernSwitzerland

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