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Age-related differences in the prevalence of subtypes of Neovascular age-related macular degeneration in the first diagnosed eye

  • Jae Hui KimEmail author
  • Young Suk Chang
  • Jong Woo Kim
  • Chul Gu Kim
  • Dong Won Lee
Retinal Disorders

Abstract

Purpose

To evaluate age-related differences in the prevalence of subtypes of neovascular age-related macular degeneration (AMD) in the first diagnosed eye.

Methods

This retrospective, observational study included 1099 eyes of 1099 patients diagnosed with neovascular AMD. The neovascular AMD cases were classified into three subtypes: typical neovascular AMD, polypoidal choroidal vasculopathy (PCV), and type 3 neovascularization. The patients were divided into four groups, according to age: > 50 and < 60 years, ≥ 60 and < 70 years, ≥ 70 and < 80 years, and ≥ 80 years. Difference in the prevalence of three AMD subtypes was evaluated among the four age groups.

Results

In the age group > 50 and < 60 years, 34 (25.0%) and 102 patients (75.0%) were diagnosed with typical neovascular AMD and PCV, respectively. In the age group ≥ 60 and < 70 years, 90 (28.1%), 206 (64.4%), and 24 patients (7.5%) were diagnosed with typical neovascular AMD, PCV, and type 3 neovascularization, respectively. In the age group ≥ 70 and < 80 years, the corresponding numbers were 200 (41.9%), 197 (41.3%), and 80 (16.8%), respectively; in the age group ≥80 years, the corresponding values were 83 (50.0%), 39 (23.5%), and 44 (26.5%), respectively. A significant difference was observed in the prevalence of the subtypes of neovascular AMD among the four age groups (chi-square test, P < 0.001).

Conclusion

Subtype prevalence in newly diagnosed neovascular AMD differs significantly according to age. This result suggests that different pathophysiology may be involved in the development of different subtypes of neovascular AMD.

Keywords

Age-related macular degeneration Choroidal neovascularization Polypoidal choroidal vasculopathy Type 3 neovascularization Retinal angiomatous proliferation 

Notes

Funding

Kim’s Eye Hospital (Seoul, South Korea) provided financial support in the form of funding for English editing support. The sponsor had no role in the design or conduct of this research.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The study was approved by the institutional review board of Kim’s Eye Hospital (Seoul, South Korea). This study was conducted in accordance with the tenets of the Declaration of Helsinki.

Informed consent

Informed consent was not obtained in this study. Identifying information about participants was not presented in this study.

References

  1. 1.
    Congdon N, O'Colmain B, Klaver CC, Klein R, Munoz B, Friedman DS, Kempen J, Taylor HR, Mitchell P (2004) Causes and prevalence of visual impairment among adults in the United States. Arch Ophthalmol 122:477–485CrossRefGoogle Scholar
  2. 2.
    Buch H, Vinding T, La Cour M, Appleyard M, Jensen GB, Nielsen NV (2004) Prevalence and causes of visual impairment and blindness among 9980 Scandinavian adults: the Copenhagen city eye study. Ophthalmology 111:53–61CrossRefGoogle Scholar
  3. 3.
    Song SJ, Youm DJ, Chang Y, Yu HG (2009) Age-related macular degeneration in a screened South Korean population: prevalence, risk factors, and subtypes. Ophthalmic Epidemiol 16:304–310CrossRefGoogle Scholar
  4. 4.
    Kawasaki R, Yasuda M, Song SJ, Chen SJ, Jonas JB, Wang JJ, Mitchell P, Wong TY (2010) The prevalence of age-related macular degeneration in Asians: a systematic review and meta-analysis. Ophthalmology 117:921–927CrossRefGoogle Scholar
  5. 5.
    Park SJ, Kwon KE, Choi NK, Park KH, Woo SJ (2015) Prevalence and incidence of exudative age-related macular degeneration in South Korea: a nationwide population-based study. Ophthalmology 122:2063–2070 e2061CrossRefGoogle Scholar
  6. 6.
    Yannuzzi LA, Sorenson J, Spaide RF, Lipson B (1990) Idiopathic polypoidal choroidal vasculopathy (IPCV). Retina 10:1–8CrossRefGoogle Scholar
  7. 7.
    Yannuzzi LA, Negrao S, Iida T, Carvalho C, Rodriguez-Coleman H, Slakter J, Freund KB, Sorenson J, Orlock D, Borodoker N (2001) Retinal angiomatous proliferation in age-related macular degeneration. Retina 21:416–434CrossRefGoogle Scholar
  8. 8.
    Freund KB, Ho IV, Barbazetto IA, Koizumi H, Laud K, Ferrara D, Matsumoto Y, Sorenson JA, Yannuzzi L (2008) Type 3 neovascularization: the expanded spectrum of retinal angiomatous proliferation. Retina 28:201–211CrossRefGoogle Scholar
  9. 9.
    Coscas G, Yamashiro K, Coscas F, De Benedetto U, Tsujikawa A, Miyake M, Gemmy Cheung CM, Wong TY, Yoshimura N (2014) Comparison of exudative age-related macular degeneration subtypes in Japanese and French patients: multicenter diagnosis with multimodal imaging. Am J Ophthalmol 158:309–318 e302CrossRefGoogle Scholar
  10. 10.
    Wong CW, Yanagi Y, Lee WK, Ogura Y, Yeo I, Wong TY, Cheung CM (2016) Age-related macular degeneration and polypoidal choroidal vasculopathy in Asians. Prog Retin Eye Res 53:107–139CrossRefGoogle Scholar
  11. 11.
    Maruko I, Iida T, Saito M, Nagayama D, Saito K (2007) Clinical characteristics of exudative age-related macular degeneration in Japanese patients. Am J Ophthalmol 144:15–22CrossRefGoogle Scholar
  12. 12.
    Liu Y, Wen F, Huang S, Luo G, Yan H, Sun Z, Wu D (2007) Subtype lesions of neovascular age-related macular degeneration in Chinese patients. Graefes Arch Clin Exp Ophthalmol 245:1441–1445CrossRefGoogle Scholar
  13. 13.
    Kim JH, Chang YS, Kim JW, Lee TG, Kim CG (2015) Prevalence of subtypes of reticular pseudodrusen in newly diagnosed exudative age-related macular degeneration and polypoidal choroidal vasculopathy in Korean patients. Retina 35:2604–2612CrossRefGoogle Scholar
  14. 14.
    Ueta T, Obata R, Inoue Y, Iriyama A, Takahashi H, Yamaguchi T, Tamaki Y, Yanagi Y (2009) Background comparison of typical age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese patients. Ophthalmology 116:2400–2406CrossRefGoogle Scholar
  15. 15.
    Zhang X, Wen F, Zuo C, Li M, Chen H, Wu K (2011) Association of genetic variation on chromosome 9p21 with polypoidal choroidal vasculopathy and neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci 52:8063–8067CrossRefGoogle Scholar
  16. 16.
    Rudnicka AR, Kapetanakis VV, Jarrar Z, Wathern AK, Wormald R, Fletcher AE, Cook DG, Owen CG (2015) Incidence of late-stage age-related macular degeneration in American Whites: systematic review and meta-analysis. Am J Ophthalmol 160:85–93 e83CrossRefGoogle Scholar
  17. 17.
    Nagiel A, Sarraf D, Sadda SR, Spaide RF, Jung JJ, Bhavsar KV, Ameri H, Querques G, Freund KB (2015) Type 3 neovascularization: evolution, association with pigment epithelial detachment, and treatment response as revealed by spectral domain optical coherence tomography. Retina 35:638–647CrossRefGoogle Scholar
  18. 18.
    Rosenfeld PJ, Brown DM, Heier JS, Boyer DS, Kaiser PK, Chung CY, Kim RY (2006) Ranibizumab for neovascular age-related macular degeneration. N Engl J Med 355:1419–1431CrossRefGoogle Scholar
  19. 19.
    Brown DM, Kaiser PK, Michels M, Soubrane G, Heier JS, Kim RY, Sy JP, Schneider S (2006) Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N Engl J Med 355:1432–1444CrossRefGoogle Scholar
  20. 20.
    Cho M, Barbazetto IA, Freund KB (2009) Refractory neovascular age-related macular degeneration secondary to polypoidal choroidal vasculopathy. Am J Ophthalmol 148:70–78 e71CrossRefGoogle Scholar
  21. 21.
    Hatz K, Prunte C (2014) Polypoidal choroidal vasculopathy in Caucasian patients with presumed neovascular age-related macular degeneration and poor ranibizumab response. Br J Ophthalmol 98:188–194CrossRefGoogle Scholar
  22. 22.
    Koh AH, Chen LJ, Chen SJ, Chen Y, Giridhar A, Iida T, Kim H, Yuk Yau Lai T, Lee WK, Li X, Han Lim T, Ruamviboonsuk P, Sharma T, Tang S, Yuzawa M (2013) Polypoidal choroidal vasculopathy: evidence-based guidelines for clinical diagnosis and treatment. Retina 33:686–716CrossRefGoogle Scholar
  23. 23.
    Mrejen S, Jung JJ, Chen C, Patel SN, Gallego-Pinazo R, Yannuzzi N, Xu L, Marsiglia M, Boddu S, Freund KB (2015) Long-term visual outcomes for a treat and extend anti-vascular endothelial growth factor regimen in eyes with neovascular age-related macular degeneration. J Clin Med 4:1380–1402CrossRefGoogle Scholar
  24. 24.
    Daniel E, Shaffer J, Ying GS, Grunwald JE, Martin DF, Jaffe GJ, Maguire MG (2016) Outcomes in eyes with retinal angiomatous proliferation in the comparison of age-related macular degeneration treatments trials (CATT). Ophthalmology 123:609–616CrossRefGoogle Scholar
  25. 25.
    Gross NE, Aizman A, Brucker A, Klancnik JM Jr, Yannuzzi LA (2005) Nature and risk of neovascularization in the fellow eye of patients with unilateral retinal angiomatous proliferation. Retina 25:713–718CrossRefGoogle Scholar
  26. 26.
    Chang YS, Kim JH, Yoo SJ, Lew YJ, Kim J (2016) Fellow-eye neovascularization in unilateral retinal angiomatous proliferation in a Korean population. Acta Ophthalmol 94:e49–e53CrossRefGoogle Scholar
  27. 27.
    Laude A, Cackett PD, Vithana EN, Yeo IY, Wong D, Koh AH, Wong TY, Aung T (2010) Polypoidal choroidal vasculopathy and neovascular age-related macular degeneration: same or different disease? Prog Retin Eye Res 29:19–29CrossRefGoogle Scholar
  28. 28.
    Chung SE, Kang SW, Lee JH, Kim YT (2011) Choroidal thickness in polypoidal choroidal vasculopathy and exudative age-related macular degeneration. Ophthalmology 118:840–845CrossRefGoogle Scholar
  29. 29.
    Kim JH, Chang YS, Lee TG, Kim CG (2015) Choroidal vascular hyperpermeability and punctate hyperfluorescent spot in choroidal neovascularization. Invest Ophthalmol Vis Sci 56:1909–1915CrossRefGoogle Scholar
  30. 30.
    Sasahara M, Tsujikawa A, Musashi K, Gotoh N, Otani A, Mandai M, Yoshimura N (2006) Polypoidal choroidal vasculopathy with choroidal vascular hyperpermeability. Am J Ophthalmol 142:601–607CrossRefGoogle Scholar
  31. 31.
    Ma L, Li Z, Liu K, Rong SS, Brelen ME, Young AL, Kumaramanickavel G, Pang CP, Chen H, Chen LJ (2015) Association of genetic variants with polypoidal choroidal vasculopathy: a systematic review and updated meta-analysis. Ophthalmology 122:1854–1865CrossRefGoogle Scholar
  32. 32.
    Chang YS, Kim JH, Kim JW, Lee TG, Kim CG, Cho SW (2016) Polypoidal choroidal vasculopathy in patients aged less than 50 years: characteristics and 6-month treatment outcome. Graefes Arch Clin Exp Ophthalmol 254:1083–1089CrossRefGoogle Scholar
  33. 33.
    Pang CE, Freund KB (2015) Pachychoroid neovasculopathy. Retina 35:1–9CrossRefGoogle Scholar
  34. 34.
    Balaratnasingam C, Lee WK, Koizumi H, Dansingani K, Inoue M, Freund KB (2016) Polypoidal choroidal vasculopathy: a distinct disease or manifestation of many? Retina 36:1–8CrossRefGoogle Scholar
  35. 35.
    Lee WK, Baek J, Dansingani KK, Lee JH, Freund KB (2016) Choroidal morphology in eyes with polypoidal choroidal vasculopathy and normal or subnormal subfoveal choroidal thickness. Retina.  https://doi.org/10.1097/IAE.0000000000001346
  36. 36.
    Warrow DJ, Hoang QV, Freund KB (2013) Pachychoroid pigment epitheliopathy. Retina 33:1659–1672CrossRefGoogle Scholar
  37. 37.
    Querques G, Querques L, Forte R, Massamba N, Blanco R, Souied EH (2013) Precursors of type 3 neovascularization: a multimodal imaging analysis. Retina 33:1241–1248CrossRefGoogle Scholar
  38. 38.
    Kim JH, Kim JR, Kang SW, Kim SJ, Ha HS (2013) Thinner choroid and greater drusen extent in retinal angiomatous proliferation than in typical exudative age-related macular degeneration. Am J Ophthalmol 155:743–749 749 e741–742CrossRefGoogle Scholar
  39. 39.
    Lee JE, Shin MK, Chung IY, Lee JE, Kim HW, Lee SJ, Park SW, Byon IS (2016) Topographical relationship between the choroidal watershed zone and submacular idiopathic choroidal neovascularisation. Br J Ophthalmol 100:652–659CrossRefGoogle Scholar
  40. 40.
    Lee JH, Lee WK (2016) Anti-vascular endothelial growth factor monotherapy for polypoidal choroidal vasculopathy with polyps resembling grape clusters. Graefes Arch Clin Exp Ophthalmol 254:645–651CrossRefGoogle Scholar
  41. 41.
    Park SJ, Lee JH, Woo SJ, Ahn J, Shin JP, Song SJ, Kang SW, Park KH (2014) Age-related macular degeneration: prevalence and risk factors from Korean National Health and Nutrition Examination Survey, 2008 through 2011. Ophthalmology 121:1756–1765CrossRefGoogle Scholar
  42. 42.
    Kawasaki R, Wang JJ, Ji GJ, Taylor B, Oizumi T, Daimon M, Kato T, Kawata S, Kayama T, Tano Y, Mitchell P, Yamashita H, Wong TY (2008) Prevalence and risk factors for age-related macular degeneration in an adult Japanese population: the Funagata study. Ophthalmology 115:1376–1381 1381 e1371–1372CrossRefGoogle Scholar
  43. 43.
    Cheung CM, Li X, Cheng CY, Zheng Y, Mitchell P, Wang JJ, Wong TY (2014) Prevalence, racial variations, and risk factors of age-related macular degeneration in Singaporean Chinese, Indians, and Malays. Ophthalmology 121:1598–1603CrossRefGoogle Scholar
  44. 44.
    Yadav S, Parry DG, Beare NA, Pearce IA (2017) Polypoidal choroidal vasculopathy: a common type of neovascular age-related macular degeneration in Caucasians. Br J Ophthalmol. 101:1377–1380Google Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Ophthalmology, Kim’s Eye HospitalKonyang University College of MedicineSeoulSouth Korea
  2. 2.Department of OphthalmologyKonyang University College of MedicineDaejeonSouth Korea

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