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Evaluation of retinal vasculature before and after treatment of children with obstructive sleep apnea-hypopnea syndrome by optical coherence tomography angiography

  • Haiyun Ye
  • Ce Zheng
  • Xiaoping Lan
  • Limin Zhao
  • Tong QiaoEmail author
  • Xiaoyan Li
  • Yidan Zhang
Retinal Disorders
  • 55 Downloads

Abstract

Purpose

To evaluate the effect of adenoidectomy on the brains of children with obstructive sleep apnea-hypopnea syndrome (OSAS) through observation of the alteration of retinal perfusion by optical coherence tomography angiography (OCTA).

Methods

Sixty-two children with OSAS (124 eyes; 5.94 ± 1.64 years old; 53.2% boys) were enrolled in this study. Their retinal vascular network density indices, including vascular diameter (VD), vascular area density (VAD), vessel skeleton density (VSD), vessel perimeter index (VPI) on the macular superficial/deep capillary plexus (SCP/DCP), and the size of the foveal avascular zone (FAZ) were analyzed by OCTA before treatment and at 1 month after the adenoidectomy.

Results

After the adenoidectomy, the values of VD, VAD, VSD, and VPI in the SCP/DCP of the parafovea were significantly increased (p < 0.01). The FAZ was significantly diminished in the SCP (t = 4.50, p < 0.05) and increased in the DCP (t = − 4.43, p < 0.05). The peripapillary indices in the SCP/DCP were not significantly changed (p > 0.05).

Conclusion

By improvement of hypoxia, the response of the parafoveal vessels was more sensitive than that of the peripapillary region in children with OSAS. Therefore, OCTA may be an ideal method to evaluate the changes of the retinal vascular system, which could be an effective parameter for the early evaluation of adenoidectomy on cases of pediatric OSAS.

Keywords

OSAS OCTA FAZ Vessel density Retinal microvasculature 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Research involving human participants

All procedures performed in studies involving human participants were in accordance with the ethical standards of Institutional Review Board of the Shanghai Children’s Hospital and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in this study.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Haiyun Ye
    • 1
  • Ce Zheng
    • 1
  • Xiaoping Lan
    • 2
  • Limin Zhao
    • 3
  • Tong Qiao
    • 1
    Email author
  • Xiaoyan Li
    • 3
  • Yidan Zhang
    • 1
  1. 1.Department of OphthalmologyShanghai Children’s Hospital, Shanghai Jiao Tong UniversityShanghaiChina
  2. 2.Department of Clinical LaboratoryShanghai Children’s Hospital, Shanghai Jiao Tong UniversityShanghaiChina
  3. 3.Department of Otolaryngology Head and Neck SurgeryShanghai Children’s Hospital, Shanghai Jiao Tong UniversityShanghaiChina

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