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Intracameral cefuroxime and the incidence of post-cataract endophthalmitis: an Israeli experience

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Abstract

Purpose

The European Society of Cataract & Refractive Surgeons (ESCRS) study reported a decrease in endophthalmitis rates from 0.34 % to 0.08 % with the use of intracameral cefuroxime. The purpose of this study was to compare the endophthalmitis rates before and after the introduction of intracameral cefuroxime (ICC) routinely at the end of cataract surgery.

Methods

A retrospective consecutive cohort study. We compared the rates of endophthalmitis between the years 2000–2006, and the years 2007–2014, after the pivotal publication of the ESCRS. Data collected included age, gender, culture results, initial and final visual acuity, and complications. Only patients that presented with endophthalmitis following cataract surgery performed at the two centers were included.

Results

Twenty-two cases of endophthalmitis occurred between the years 2000 and 2006, out of 26,663 cataract operations performed at the two centers, a rate of 0.083 %. Ten cases occurred between the years 2007 and 2014 out of 29,431 cataract operations, a rate of 0.034 %. The difference was statistically significant (p = 0.03)

Conclusions

The introduction of prophylactic use of intracameral cefuroxime was associated with a significant reduction in post-operative endophthalmitis rates in our centers. We strongly recommend adoption of this routine by for all cataract operations except when contraindicated.

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Conflict of interest

All authors certify that they have NO affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

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Authors and Affiliations

  1. Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, 52621, Israel

    Gabriel Katz, Sharon Blum & Joseph Moisseiev

  2. Ophthalmology Department, Rabin Medical Center, Petah Tikva, Israel

    Omer Leeva, Ruth Axer-Siegel, Gili Tesler & Rita Ehrlich

Authors
  1. Gabriel Katz
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  2. Sharon Blum
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  3. Omer Leeva
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  4. Ruth Axer-Siegel
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  5. Joseph Moisseiev
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  6. Gili Tesler
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  7. Rita Ehrlich
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Corresponding author

Correspondence to Gabriel Katz.

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Katz, G., Blum, S., Leeva, O. et al. Intracameral cefuroxime and the incidence of post-cataract endophthalmitis: an Israeli experience. Graefes Arch Clin Exp Ophthalmol 253, 1729–1733 (2015). https://doi.org/10.1007/s00417-015-3009-z

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  • DOI: https://doi.org/10.1007/s00417-015-3009-z

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