Susac’s syndrome as an immune-related adverse event after pembrolizumab: a case report

  • M. De GrootEmail author
  • A. Compter
  • A. J. De Langen
  • D. Brandsma
Letter to the Editors

Dear Sirs,

Immune checkpoint inhibitors are increasingly used in cancer treatment and have a significant impact on survival [1]. Pembrolizumab is a recombinant monoclonal antibody that blocks the programmed death-1 (PD-1) receptor, which is an inhibitor of T-cell activation, and thereby can promote the immune response against the tumor [2]. The increased immune response can also induce auto-immune side effects [3]. For the first time, we report a case of Susac’s syndrome induced by pembrolizumab.

A 55-year-old woman was diagnosed with stage IV non-small cell lung cancer (NSCLC) with metastases in the adrenal gland, bones and brain. The primary tumor was thyroid transcription factor-1 (TTF-1) positive and tested negative for oncogenic drivers, including epidermal growth factor receptor (EGFR), B-Raf proto-oncogene serine/threonine kinase (BRAF), anaplastic lymphoma kinase (ALK), ROS proto-oncogene 1 receptor tyrosine kinase (ROS1) and KRAS proto-oncogene GTPase (KRAS). Oncogenic drivers...


Compliance with ethical standards

Conflicts of interest

The authors declare that they have no competing interests.

Ethical standards

The patient provided informed oral and written consent in accordance with specific national laws and the ethics standards laid down in the 1964 Declaration of Helsinki and its later amendments.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • M. De Groot
    • 1
    Email author
  • A. Compter
    • 1
  • A. J. De Langen
    • 2
  • D. Brandsma
    • 1
  1. 1.Department of Neuro-OncologyNetherlands Cancer Institute-Antoni Van LeeuwenhoekAmsterdamThe Netherlands
  2. 2.Department of Thoracic OncologyNetherlands Cancer Institute-Antoni Van LeeuwenhoekAmsterdamThe Netherlands

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