Advertisement

Journal of Neurology

, Volume 266, Supplement 1, pp 146–148 | Cite as

Electrical brain stimulation of the parietal lobe impairs the perception of verticality

  • O. KremmydaEmail author
  • V. Kirsch
  • S. Bardins
  • H. Lohr
  • C. Vollmar
  • S. Noachtar
  • M. Dieterich
Letter to the Editors
  • 104 Downloads

Dear Sirs,

The aim of the current case study was to determine the critical causative vestibular areas that manifest with vertigo and perceptual deficits of verticality using electrical brain stimulation.

A 29-year-old right-handed woman received 15 intracranial multicontact electrodes (12 depth and 3 subdural strips) for presurgical evaluation of a pharmacoresistant right focal epilepsy of unknown origin. The patient had suffered from versive seizures to the left, tonic seizures of the left arm, and generalized tonic–clonic seizures for 10 years. Invasive EEG monitoring showed a right frontal seizure onset (cortical contacts of electrodes A and D, Fig.  1b). The neurological examination, including neurootological examination of the oculomotor and vestibular system, was normal.

Notes

Acknowledgements

Partially funded by the Society for the Advancement of Science and Research at the Medical Faculty of the Ludwig-Maximilian University, Munich, the Graduate School of Systemic Neurosciences (GSN), the German Foundation for Neurology (DSN), and the German Federal Ministry of Education and Research (German Center for Vertigo and Balance Disorders, Grant code 01EO140). We thank C. Frenzel, F. Ihl and M. Klemm for assistance in orthoptic examinations and Katie Göttlinger for copyediting the manuscript.

Compliance with ethical standards

Conflicts of interests

S. Bardins is shareholder of EyeSeeTec GmbH, manufacturer of the eye-tracking equipment used in the study.

Ethical standards

The study was performed in accordance with the declaration of Helsinki

Informed consent

The patient gave her informed consent for the measurements.

References

  1. 1.
    Baysal-Kirac L, Hartl E, Vollmar C, Ernst K, Lohr H, Noachtar S (2018) Stimulation-induced ictal vocalisation of left frontal lobe origin. Epileptic Disord 20(5):418–422.  https://doi.org/10.1684/epd.2018.0990 CrossRefPubMedGoogle Scholar
  2. 2.
    Zwergal A, Rettinger N, Frenzel C, Dieterich M, Brandt T, Strupp M (2009) A bucket of static vestibular function. Neurology 72(19):1689–1692.  https://doi.org/10.1212/WNL.0b013e3181a55ecf CrossRefPubMedGoogle Scholar
  3. 3.
    Dieterich M, Brandt T (2019) Perception of verticality and vestibular disorders of balance and falls. Front Neurol 10:172.  https://doi.org/10.3389/fneur.2019.00172 CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Baier B, Suchan J, Karnath HO, Dieterich M (2012) Neural correlates of disturbed perception of verticality. Neurology 78(10):728–735.  https://doi.org/10.1212/WNL.0b013e318248e544 CrossRefPubMedGoogle Scholar
  5. 5.
    Selimbeyoglu A, Parvizi J (2010) Electrical stimulation of the human brain: perceptual and behavioral phenomena reported in the old and new literature. Front Hum Neurosci 4:46.  https://doi.org/10.3389/fnhum.2010.00046 CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    Kahane P, Hoffmann D, Minotti L, Berthoz A (2003) Reappraisal of the human vestibular cortex by cortical electrical stimulation study. Ann Neurol 54(5):615–624.  https://doi.org/10.1002/ana.10726 CrossRefPubMedGoogle Scholar
  7. 7.
    Caruana F, Gerbella M, Avanzini P, Gozzo F, Pelliccia V, Mai R, Abdollahi RO, Cardinale F, Sartori I, Lo Russo G, Rizzolatti G (2018) Motor and emotional behaviours elicited by electrical stimulation of the human cingulate cortex. Brain 141(10):3035–3051.  https://doi.org/10.1093/brain/awy219 CrossRefPubMedGoogle Scholar
  8. 8.
    Fischer E, Bulthoff HH, Logothetis NK, Bartels A (2012) Visual motion responses in the posterior cingulate sulcus: a comparison to V5/MT and MST. Cereb Cortex 22(4):865–876.  https://doi.org/10.1093/cercor/bhr154 CrossRefPubMedGoogle Scholar
  9. 9.
    Kataoka H, Sugie K, Kohara N, Ueno S (2006) Novel representation of astasia associated with posterior cingulate infarction. Stroke 37(1):e3–5.  https://doi.org/10.1161/01.STR.0000195046.89926.98 CrossRefPubMedGoogle Scholar
  10. 10.
    Anagnostou E, Spengos K, Vassilopoulou S, Paraskevas GP, Zis V, Vassilopoulos D (2010) Incidence of rotational vertigo in supratentorial stroke: a prospective analysis of 112 consecutive patients. J Neurol Sci 290(1–2):33–36.  https://doi.org/10.1016/j.jns.2009.11.015 CrossRefPubMedGoogle Scholar
  11. 11.
    Dieterich M, Brandt T (2015) Why acute unilateral vestibular cortex lesions mostly manifest without vertigo. Neurology 84(16):1680–1684.  https://doi.org/10.1212/WNL.0000000000001501 CrossRefPubMedGoogle Scholar
  12. 12.
    von Brevern M, Sussmilch S, Zeise D (2014) Acute vertigo due to hemispheric stroke: a case report and comprehensive review of the literature. J Neurol Sci 339(1–2):153–156.  https://doi.org/10.1016/j.jns.2014.02.005 CrossRefGoogle Scholar
  13. 13.
    Willacker L, Dowsett J, Dieterich M, Taylor PCJ (2019) Egocentric processing in the roll plane and dorsal parietal cortex: a TMS-ERP study of the subjective visual vertical. Neuropsychologia 127:113–122.  https://doi.org/10.1016/j.neuropsychologia.2019.02.023 CrossRefPubMedGoogle Scholar
  14. 14.
    Otero-Millan J, Winnick A, Kheradmand A (2018) Exploring the role of temporoparietal cortex in upright perception and the link with torsional eye position. Front Neurol 9:192.  https://doi.org/10.3389/fneur.2018.00192 CrossRefPubMedPubMedCentralGoogle Scholar
  15. 15.
    Kirsch V, Keeser D, Hergenroeder T, Erat O, Ertl-Wagner B, Brandt T, Dieterich M (2016) Structural and functional connectivity mapping of the vestibular circuitry from human brainstem to cortex. Brain Struct Funct 221(3):1291–1308.  https://doi.org/10.1007/s00429-014-0971-x CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • O. Kremmyda
    • 1
    • 2
    Email author
  • V. Kirsch
    • 1
    • 3
  • S. Bardins
    • 2
  • H. Lohr
    • 1
  • C. Vollmar
    • 1
  • S. Noachtar
    • 1
    • 3
  • M. Dieterich
    • 1
    • 2
    • 3
    • 4
  1. 1.Department of NeurologyLudwig Maximilian UniversityMunichGermany
  2. 2.German Center for Vertigo and Balance Disorders-IFBLMULudwig Maximilian UniversityMunichGermany
  3. 3.Graduate School of Systemic NeuroscienceLudwig Maximilian UniversityMunichGermany
  4. 4.Munich Cluster for Systems Neurology (SyNergy)MunichGermany

Personalised recommendations