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Journal of Neurology

, Volume 266, Issue 2, pp 487–497 | Cite as

The dual role of cognitive reserve in subjective cognitive decline and mild cognitive impairment: a 7-year follow-up study

  • Salvatore Mazzeo
  • Sonia Padiglioni
  • Silvia Bagnoli
  • Laura Bracco
  • Benedetta Nacmias
  • Sandro Sorbi
  • Valentina BessiEmail author
Original Communication

Abstract

The aim of this study was to evaluate the effect of cognitive reserve (CR), in progression from subjective cognitive decline (SCD) to mild cognitive impairment (MCI) and Alzheimer’s disease (AD). For this purpose, we followed up 263 patients (154 SCD; 109 MCI) for a mean time of 7 years. CR was assessed by the Test di Intelligenza Breve (TIB), functionally equivalent to the National Adult Reading Test. High CR resulted as a protective factor for progression from SCD to MCI. Age at conversion to MCI was delayed 9 years on average in SCD with high CR with respect to SCD with low CR. On the contrary, high CR resulted as a risk factor for progression from MCI to AD dementia only in APOE ε4 carriers. Conversion time from MCI to AD dementia was 3 years shorter in ε4 carriers with high CR than subjects with low CR and ε4 non-carriers with high CR. Consistent with the CR hypothesis, our results showed that higher levels of CR protect against the earliest clinical manifestations of AD. In line with the previous researches, we found an interaction between CR and APOE in progression from MCI to AD dementia.

Keywords

Alzheimer’s disease Subjective cognitive decline Mild cognitive impairment APOE Cognitive reserve Neuropsychology 

Abbreviations

CR

Cognitive reserve

SCD

Subjective cognitive decline

TIB

Test di Intelligenza Breve

HDRS

Hamilton Depression Rating Scale

NART

National adult reading test

Notes

Acknowledgements

This research was funded by Ministero della Salute and Regione Toscana (Grants n° GR-2010-2316359—Longitudinal clinical–neuropsychological study of subjective memory complaints).

Compliance with ethical standards

Conflicts of interest

The authors have no conflict of interest to report.

Ethical standards

All procedures involving experiments on human subjects have been done in accordance with the ethical standards of the Committee on Human Experimentation of the institution in which the experiments were done or in accordance with the Helsinki Declaration of 1975. Specific national laws have been observed.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Salvatore Mazzeo
    • 1
  • Sonia Padiglioni
    • 1
  • Silvia Bagnoli
    • 1
  • Laura Bracco
    • 1
  • Benedetta Nacmias
    • 1
  • Sandro Sorbi
    • 1
    • 2
  • Valentina Bessi
    • 1
    Email author
  1. 1.Department of Neuroscience, Psychology, Drug Research and Child HealthUniversity of Florence, Azienda Ospedaliero-Universitaria CareggiFlorenceItaly
  2. 2.IRCCS Fondazione Don Carlo GnocchiFlorenceItaly

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