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Journal of Neurology

, Volume 266, Issue 2, pp 476–479 | Cite as

Characteristics of single ocular motor nerve palsy associated with anti-GQ1b antibody

  • Kwang-Dong Choi
  • Seo Young Choi
  • Jae-Hwan Choi
  • Seong Hi Kim
  • Seong-Han Lee
  • Seong-Hae Jeong
  • Hyo-Jung Kim
  • Jeong-Yoon Choi
  • Ji-Soo KimEmail author
Original Communication
  • 160 Downloads

Abstract

To define the prevalence and characteristics of single ocular motor nerve palsy (OMNP) associated with positive serum anti-GQ1b antibody. We performed a prospective multicenter study that recruited 82 patients with single OMNP without identifiable causes from the history and neuroimaging in six neurology clinics of university hospitals. We measured serum anti-GQ1b antibody in all participants. Twelve patients with multiple OMNP and 30 with identifiable causes served as the controls. Overall, the prevalence of anti-GQ1b antibody syndrome was 10% (8/82) in patients with single OMNP and 6% (5/78) in those with single OMNP in isolation. None of the 14 patients with OMNP with identifiable causes showed positive serum anti-GQ1b antibody. The prevalence of anti-GQ1b antibody syndrome was much higher in patients with multiple OMNP than in those with single OMNP (50% vs. 10%, p < 0.01). Patients with single OMNP and positive anti-GQ1b antibody are younger (42 ± 16 vs. 58 ± 15, p < 0.05) and had a significantly higher frequency of preceding infection (75 vs. 19%, p < 0.05) and other neurological signs (38 vs. 1%, p < 0.05) than those with negative antibody. Eight patients with single OMNP and positive serum anti-GQ1b antibody involved the abducens (n = 6), trochlear (n = 1), or oculomotor nerve (n = 1). Single OMNP accompanying other neurological signs and multiple OMNP are more likely to be associated with anti-GQ1b antibody. Anti-GQ1b antibody syndrome should be considered even in patients with single OMNP, especially when antecedent infection was associated in younger patients.

Keywords

Acquired ocular motor nerve palsy Isolated ocular motor nerve palsy Anti-GQ1b antibody Anti-ganglioside antibody Fisher syndrome 

Notes

Compliance with ethical standards

Conflicts of interest

We have no disclosure of any competing interest.

Ethical approval for research involving human participants and/or animals

All experiments followed the tenets of the Declaration of Helsinki, and this study was approved by the Institutional Review Board of Pusan National University Hospital (1605-001-041).

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Neurology, Biomedical Research InstitutePusan National University Hospital, Pusan National University School of MedicineBusanSouth Korea
  2. 2.Department of Neurology, Biomedical Research InstitutePusan National University Yangsan Hospital, Pusan National University School of MedicineBusanSouth Korea
  3. 3.Department of NeurologyKyungpook National University School of MedicineDaeguSouth Korea
  4. 4.Department of NeurologyChonnam National University Medical School, Chonnam National University HospitalGwangjuSouth Korea
  5. 5.Department of NeurologyChungnam National University School of MedicineDaejeonSouth Korea
  6. 6.Department of Neurology, Dizziness CenterSeoul National University Bundang HospitalSeongnamSouth Korea
  7. 7.Research Administration TeamSeoul National University Bundang HospitalSeongnamSouth Korea
  8. 8.Department of NeurologySeoul National University College of Medicine, Seoul National University Bundang HospitalSeongnamSouth Korea

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