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Journal of Neurology

, Volume 266, Issue 2, pp 522–524 | Cite as

Sez6l2-antibody-associated progressive cerebellar ataxia: a differential diagnosis of atypical parkinsonism

  • Max Borsche
  • Stefanie Hahn
  • Henrike Hanssen
  • Alexander Münchau
  • Klaus-Peter Wandinger
  • Norbert BrüggemannEmail author
Letter to the Editors
  • 62 Downloads

Dear Sirs,

Recent advances in the identification of immunological causes for movement disorders have opened a new avenue to causally treat these often severely disabling diseases. Immunological processes may be related to secondary underlying disease causes or may occur without known association to such conditions. The detection of antibodies against intracellular structures or surface antigens may be helpful in the diagnostic workup although their significance with regard to disease mechanisms is controversial. Thus, the presence of an antibody may be unspecific, may serve as a biomarker indicating an underlying autoimmunological process or may directly be involved in the disease process. Complicating matters, antibody-associated neurological syndromes may occur without overt inflammatory signs, particularly in the elderly population [1].

Here, we report the second patient with rapidly progressive cerebellar ataxia and anti-Sez6l2 antibodies. We highlight additional clinical signs...

Notes

Funding

None.

Compliance with ethical standards

Conflicts of interest

The authors declare that they have no competing interests.

Supplementary material

Supplementary material 1 (MOV 12880 KB)

Supplementary material 2 (MOV 16607 KB)

Supplementary material 3 (MOV 23917 KB)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Institute of NeurogeneticsUniversity of LübeckLübeckGermany
  2. 2.Institute of Experimental ImmunologyEuroimmun AGLübeckGermany
  3. 3.Department of NeurologyUniversity of LübeckLübeckGermany
  4. 4.Institute of Clinical ChemistryUniversity Hospital of Schleswig-HolsteinLübeckGermany

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