Journal of Neurology

, Volume 265, Issue 12, pp 2944–2948 | Cite as

Elevated C-reactive protein and white blood cell count at admission predict functional outcome after non-aneurysmal subarachnoid hemorrhage

  • Patrick SchussEmail author
  • Alexis Hadjiathanasiou
  • Simon Brandecker
  • Ági Güresir
  • Hartmut Vatter
  • Erdem Güresir
Original Communication



Patients with non-aneurysmal subarachnoid hemorrhage (SAH) are considered to have an overall benign course of disease compared to patients suffering from aneurysmal SAH. Nevertheless, a small but significant number of such patients might only achieve unfavorable outcome. Therefore, the purpose of the present study was to determine if routine laboratory markers of acute phase response are associated with unfavorable outcome in patients with non-aneurysmal SAH.


From 2006 to 2017, 154 patients suffering from non-aneurysmal SAH were admitted to our institution. Patients were stratified according to the distribution of cisternal blood into patients with perimesencephalic SAH (pSAH) versus non-perimesencephalic SAH (npSAH). C-reactive protein (CRP) and white blood cells (WBC) assessments were performed within 24 h of admission as part of routine laboratory workup. Outcome was assessed according to the modified Rankin Scale (mRS) after 6 months and stratified into favorable (mRS 0–2) vs. unfavorable (mRS 3–6).


The multivariate regression analysis revealed “CRP > 5 mg/l” (p = 0.004, OR 143.7), “WBC count > 12.1 G/l” (p = 0.006, OR 47.8), “presence of IVH” (p = 0.02, OR 13.5), “poor-grade SAH” (p = 0.01, OR 45.2) and “presence of CVS” (p = 0.003, OR 149.9) as independently associated with unfavorable outcome in patients with non-aneurysmal SAH.


Elevated C-reactive protein and WBC count at admission were associated with unfavorable outcome after non-aneurysmal SAH.


Non-aneurysmal subarachnoid hemorrhage Outcome Perimesencephalic C-reactive protein 


Compliance with ethical standards

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

The present study was approved by the local ethics committee.

Informed consent

Informed consent was not sought as a retrospective study design was used.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Patrick Schuss
    • 1
    Email author
  • Alexis Hadjiathanasiou
    • 1
  • Simon Brandecker
    • 1
  • Ági Güresir
    • 1
  • Hartmut Vatter
    • 1
  • Erdem Güresir
    • 1
  1. 1.Department of NeurosurgeryRheinische Friedrich-Wilhelms-University BonnBonnGermany

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