Journal of Neurology

, Volume 265, Issue 11, pp 2743–2744 | Cite as

Ciclosporin and chorea: a new association?

  • Montserrat García
  • Juan Luis Haro-Gonzalez
  • Carmelo Aguirre
Letter to the Editors

Dear Sirs,

Ciclosporin neurotoxicity is observed in 10–60% of transplanted patients [1, 2]. We describe a case of chorea in a heart transplant patient treated with ciclosporin.

In 1997, a 68-year-old man received a heart transplant due to diffuse coronary disease. In February 2016, he sought medical attention for cognitive impairment (Mini-Mental State Examination, MMSE = 27) and chorea-like abnormal involuntary movements together with hyperglycaemia (418 mg/dL). By May 2017, he showed worsening chorea-like movements and progressive difficulty walking. Subsequently, he had three hospital admissions (two in July 2017 and one in August 2017) for chorea, with more marked movements, and difficulty caring for him at home, with frequent choking, loss of sphincter control, and inability to perform basic activities (eat using cutlery, drink water). During these admissions, his blood glucose levels were 243 mg/dL (May 2017), 143 mg/dL (July 2017), and 244 mg/dL (August 2017). He was being...


Compliance with ethical standards

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical standards

The study was approved by the ethics committee of hospital.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Basque Country Pharmacovigilance UnitGaldakao-Usansolo HospitalGaldakaoSpain
  2. 2.Department of Internal MedicineSan Eloy HospitalBarakaldoSpain
  3. 3.Department of Pharmacology, Faculty of Medicine and NursingUniversity of the Basque CountryLeioaSpain

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