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Journal of Neurology

, Volume 265, Issue 11, pp 2562–2572 | Cite as

Neural correlates of changes in sexual function in frontotemporal dementia: implications for reward and physiological functioning

  • Rebekah M. Ahmed
  • Zoë-lee Goldberg
  • Cassandra Kaizik
  • Matthew C. Kiernan
  • John R. Hodges
  • Olivier Piguet
  • Muireann Irish
Original Communication

Abstract

Background

Frontotemporal dementia (FTD) is characterised by changes in behaviour including alterations in sexual function. While hypersexual behaviour is commonly thought to predominate, emerging evidence suggests that hyposexual behaviour is in fact most prevalent. The underlying mechanisms driving these behavioural changes remain unclear; however, likely reflect interactions between cognitive, emotional, reward processing and physiological functioning. We aimed to systematically quantify changes in sexual behaviour in behavioural variant FTD (bvFTD) and semantic dementia (SD) in contrast with Alzheimer’s disease (AD) and to elucidate the neural correlates of these changes using whole-brain voxel-based morphometry.

Methods

Carers of 62 dementia patients (30 bvFTD, 12 SD, 20 AD) were interviewed using the Sexual Behaviour and Intimacy Questionnaire, which assesses changes in sexual function. Voxel-based morphometry analysis of structural MRI brain scans was used to determine the association between changes in grey matter intensity and the presence of hyposexual, hypersexual, and inappropriate sexual behaviour across groups.

Results

Widespread attenuation of sexual drive, intimacy and the display of affection were evident irrespective of dementia subtype. In contrast, hypersexual and inappropriate sexual behaviour was present in only a small proportion of patients. Neuroimaging analyses revealed an association between hyposexual behaviour and atrophy of the right supramarginal gyrus, middle frontal gyrus and thalamus, whilst hypersexual behaviour was associated with cerebellar atrophy.

Conclusion

Counter to the prevailing view, younger-onset dementia syndromes predominantly display an attenuation in sexual drive. Changes in sexual function likely reflect the degeneration of cortical and subcortical neural circuits implicated in reward, autonomic function, empathy, and emotional processing.

Keywords

Frontotemporal dementia Alzheimer’s disease Reward Physiology Sexual function Hypothalamus Neurodegeneration Neuroendocrine 

Notes

Funding

This work was supported in part by funding to Forefront, a collaborative research group dedicated to the study of frontotemporal dementia and amyotrophic lateral sclerosis, from the National Health and Medical Research Council of Australia (NHMRC) programme grant (#1037746 to MK and JH) and the Australian Research Council Centre of Excellence in Cognition and its Disorders Memory Program (#CE110001021 to OP and JH). We are grateful to the research participants involved with the ForeFront research studies. RA is a NHMRC Early Career Fellow (#1120770). OP is a NHMRC Senior Research Fellow (#1103258). MI is supported by an Australian Research Council Future Fellowship (FT160100096).

Compliance with ethical standards

Conflicts of interest

No author reports any conflict of interest. MCK is Editor in chief of Journal of Neurology Neurosurgery and Psychiatry.

Supplementary material

415_2018_9024_MOESM1_ESM.docx (26 kb)
Supplementary material 1 (DOCX 26 KB)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Rebekah M. Ahmed
    • 1
    • 2
  • Zoë-lee Goldberg
    • 3
  • Cassandra Kaizik
    • 1
    • 2
  • Matthew C. Kiernan
    • 1
    • 2
  • John R. Hodges
    • 1
    • 4
  • Olivier Piguet
    • 3
    • 4
  • Muireann Irish
    • 3
    • 4
  1. 1.ForeFront Clinic, Sydney Medical School, Brain and Mind CentreThe University of SydneySydneyAustralia
  2. 2.Memory and Cognition Clinic, Institute of Clinical NeurosciencesRoyal Prince Alfred HospitalSydneyAustralia
  3. 3.School of Psychology and Brain and Mind CentreThe University of SydneySydneyAustralia
  4. 4.ARC Centre of Excellence in Cognition and its DisordersSydneyAustralia

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