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Differential long-term evolution after surgery or pharmacotherapy of Rasmussen encephalopathy in adult patients

  • Annalisa ParenteEmail author
  • Chiara Pastori
  • Flavio Villani
  • Anna Rita Giovagnoli
Letter to the Editors
  • 30 Downloads

Dear Sir,

Rasmussen encephalitis (RE) is a severe encephalopathy marked by a chronic brain inflammation including microglial nodules, perivascular infiltrates, neuronal loss and gliosis [1], which typically affects one hemisphere. Although clinical onset is usually in the childhood, some cases begin in the adolescence or young adulthood. Clinically, it is characterized by drug-resistant seizures, often epilepsia partialis continua (EPC) and epileptic status, motor and sensorial impairments, cognitive impairments secondary to progressive brain dysfunction. Magnetic resonance shows progressive unilateral atrophy of the cortex, caudate nucleus and signal alteration of the white matter. Treatment is aimed at controlling the seizures and stopping clinical worsening. To date, the surgical exclusion of the affected hemisphere has been the only therapeutic option to achieve both objectives [2, 3]. Functional hemispherectomy of the affected hemisphere is unanimously recognized as the treatment...

Notes

Compliance with ethical standards

Conflicts of interest

The authors declare that they have no conflict of interest.

Ethical standard statement

The authors state that no approval by ethics committee is required for the issue of this letter, and that all applicable Italian laws have been observed.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.IRCCS Istituto Neurologico Carlo BestaMilanItaly

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