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Journal of Neurology

, Volume 260, Issue 10, pp 2656–2658 | Cite as

Videogame-based coordinative training can improve advanced, multisystemic early-onset ataxia

  • Matthis SynofzikEmail author
  • Cornelia Schatton
  • Martin Giese
  • Julia Wolf
  • Ludger Schöls
  • Winfried Ilg
Letter to the Editors

Dear Sirs,

Treatment options are rare in neurodegenerative childhood-onset ataxias, especially if presenting in advanced disease stages and with multisystemic disease load. Moreover, wheelchair-bound children and young adults with ataxia are commonly excluded from current drug treatment trials [1, 2], thus leaving them without prospects of access to novel treatments. Using a rater-blinded intraindividual control design, we here provide first proof-of-principle evidence that videogame-based coordinative training might serve as an effective treatment even for advanced, multisystemic degenerative ataxia.

A 10-year-old boy suffering from genetically confirmed Ataxia Telangiectasia (compound heterozygous ATMp.Glu2596Aspfs*4 and p.Asp1625_Ala2626delinsGluPro) since 3 years of age and wheelchair-bound with only residual standing and walking capacities since 7 years of age (clinical details, Supplement 1) was recruited for a sequentially structured 12-week coordinative training program based...

Keywords

Advanced Disease Stage Ataxia Telangiectasia Spinocerebellar Pathway Residual Standing Subjective Achievement 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

We are particularly thankful to the index patient and his family for participating in this study, to Dr. Dirk Heinicke (Klinik Bavaria, Kreischa, Germany) for referring this patient to us, and to Dr. Anne Söhn (Institute for Medical Genetics, Tübingen) for clarifying the terminology of the reported mutations. This study was supported by Ataxia UK, Ataxia Ireland, the German Hereditary Ataxia Foundation (DHAG), and the Katarina Witt-Stiftung.

Conflicts of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest. The following authors report financial disclosures: Dr. Synofzik received a research grant by the Robert-Bosch Stiftung and AtaxiaUK/Ataxia Ireland, and consulting fees from Actelion Pharmaceuticals Ltd.; Dr. Giese is supported by EC FP7-ICT-248311 AMARSi, Fp7-PEOPLE-2011-ITN ABC, The Human Brain Project, and Deutsche Forschungsgemeinschaft: DFG GI 305/4-1, DFG GZ: KA 1258/15-1, and the German Federal Ministry of Education and Research: BMBF, FKZ: 01GQ1002A.

Supplementary material

415_2013_7087_MOESM1_ESM.docx (302 kb)
Supplementary material 1 (DOCX 301 kb)

Supplementary material 2 (MP4 15314 kb)

References

  1. 1.
    Zannolli R, Buoni S, Betti G et al (2012) A randomized trial of oral betamethasone to reduce ataxia symptoms in ataxia telangiectasia. Mov Disord 27(10):1312–1316PubMedCrossRefGoogle Scholar
  2. 2.
    Lynch DR, Perlman SL, Meier T (2010) A phase 3, double-blind, placebo-controlled trial of idebenone in friedreich ataxia. Arch Neurol 67(8):941–947PubMedCrossRefGoogle Scholar
  3. 3.
    Schmitz-Hubsch T, du Montcel ST, Baliko L et al (2006) Scale for the assessment and rating of ataxia: development of a new clinical scale. Neurology 66(11):1717–1720PubMedCrossRefGoogle Scholar
  4. 4.
    Ilg W, Synofzik M, Brotz D, Burkard S, Giese MA, Schols L (2009) Intensive coordinative training improves motor performance in degenerative cerebellar disease. Neurology 73(22):1823–1830PubMedCrossRefGoogle Scholar
  5. 5.
    Ilg W, Schatton C, Schicks J, Giese MA, Schols L, Synofzik M (2012) Video game-based coordinative training improves ataxia in children with degenerative ataxia. Neurology 79(20):2056–2060PubMedCrossRefGoogle Scholar
  6. 6.
    Kiresuk TJ, Smith A, Cardillo JEE (1994) Goal attainment scaling: applications, theory and measurement. Lawrence Erlbaum Associates, Inc., HillsdaleGoogle Scholar
  7. 7.
    Marelli C, Figoni J, Charles P et al (2012) Annual change in Friedreich’s ataxia evaluated by the Scale for the Assessment and Rating of Ataxia (SARA) is independent of disease severity. Mov Disord 27(1):135–138PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Matthis Synofzik
    • 1
    • 2
    • 5
    Email author
  • Cornelia Schatton
    • 3
    • 4
  • Martin Giese
    • 3
    • 4
  • Julia Wolf
    • 1
    • 2
  • Ludger Schöls
    • 1
    • 2
  • Winfried Ilg
    • 3
    • 4
  1. 1.Department of Neurodegenerative DiseasesHertie Institute for Clinical Brain ResearchTübingenGermany
  2. 2.German Research Center for Neurodegenerative Diseases (DZNE)TübingenGermany
  3. 3.Department of Cognitive NeurologyHertie Institute for Clinical Brain ResearchTübingenGermany
  4. 4.Centre for Integrative Neuroscience (CIN)TübingenGermany
  5. 5.Department of Neurology, Hertie Institute for Clinical Brain ResearchUniversity of TübingenTübingenGermany

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