Videogame-based coordinative training can improve advanced, multisystemic early-onset ataxia
- 554 Downloads
Treatment options are rare in neurodegenerative childhood-onset ataxias, especially if presenting in advanced disease stages and with multisystemic disease load. Moreover, wheelchair-bound children and young adults with ataxia are commonly excluded from current drug treatment trials [1, 2], thus leaving them without prospects of access to novel treatments. Using a rater-blinded intraindividual control design, we here provide first proof-of-principle evidence that videogame-based coordinative training might serve as an effective treatment even for advanced, multisystemic degenerative ataxia.
KeywordsAdvanced Disease Stage Ataxia Telangiectasia Spinocerebellar Pathway Residual Standing Subjective Achievement
We are particularly thankful to the index patient and his family for participating in this study, to Dr. Dirk Heinicke (Klinik Bavaria, Kreischa, Germany) for referring this patient to us, and to Dr. Anne Söhn (Institute for Medical Genetics, Tübingen) for clarifying the terminology of the reported mutations. This study was supported by Ataxia UK, Ataxia Ireland, the German Hereditary Ataxia Foundation (DHAG), and the Katarina Witt-Stiftung.
Conflicts of interest
On behalf of all authors, the corresponding author states that there is no conflict of interest. The following authors report financial disclosures: Dr. Synofzik received a research grant by the Robert-Bosch Stiftung and AtaxiaUK/Ataxia Ireland, and consulting fees from Actelion Pharmaceuticals Ltd.; Dr. Giese is supported by EC FP7-ICT-248311 AMARSi, Fp7-PEOPLE-2011-ITN ABC, The Human Brain Project, and Deutsche Forschungsgemeinschaft: DFG GI 305/4-1, DFG GZ: KA 1258/15-1, and the German Federal Ministry of Education and Research: BMBF, FKZ: 01GQ1002A.
Supplementary material 2 (MP4 15314 kb)
- 6.Kiresuk TJ, Smith A, Cardillo JEE (1994) Goal attainment scaling: applications, theory and measurement. Lawrence Erlbaum Associates, Inc., HillsdaleGoogle Scholar