Journal of Neurology

, Volume 260, Issue 6, pp 1576–1582 | Cite as

Isolated floccular infarction: impaired vestibular responses to horizontal head impulse

  • Hong-Kyun Park
  • Ji-Soo KimEmail author
  • Michael Strupp
  • David S. Zee
Original Communication


Isolated floccular infarction is extremely rare, and impairments of the vestibulo-ocular reflex (VOR) have not been explored in humans with isolated floccular lesions. The purpose of this study was to examine and report selective impairment of VOR in response to high acceleration using head impulse in a patient with isolated floccular infarction. The patient underwent bedside and laboratory evaluation of vestibular function, which included video-oculography, ocular torsion and the subjective visual vertical, cervical and ocular vestibular-evoked myogenic potentials, bithermal caloric irrigation, rotatory chair test, and the head impulse test (HIT) using search coils. A 70-year-old woman with a unilateral floccular infarction presented with an acute vestibular syndrome with spontaneous nystagmus beating to the lesion side, impaired ipsilesional pursuit, contraversive ocular torsion and tilt of the subjective visual vertical. With rotatory chair testing at low frequencies, horizontal VOR gains were increased. However, VOR gains were decreased with the higher-frequency, higher-speed HIT. While HIT is often normal in patients with central vestibular disorders, decreased HIT responses do not exclude an isolated cerebellar lesion as a cause of the acute vestibular syndrome.


Vertigo Flocculus Cerebellum Infarction Vestibulo-ocular reflex Head impulse test 



This study was supported by a grant of Korea Medical Device Industrial Cooperative Association. Dr. Park reports no disclosures. Dr. Kim serves as an Associate Editor of Frontiers in Neuro-otology and on the Editorial Boards of the Journal of Korean Society of Clinical Neurophysiology, Research in Vestibular Science, Journal of Clinical Neurology, Frontiers in Neuro-ophthalmology, Journal of Neuro-ophthalmology, and Case Reports in Ophthalmological Medicine; and received research support from SK Chemicals, Co. Ltd., Dr. Strupp is Joint Editor-in-Chief of the Journal of Neurology and Editor-in-Chief of Frontiers of Neurology. He received research support from the German Ministry of Education and Research (BMBF) and the Deutsche Forschungsgemeinschaft (DFG) as well as from Abbott, Biogen Idec, and Pfizer. He received speaker’s honoraria from Abbott, GSK, Biogen Idec, Merck Serono, TEVA, and UCB. Dr. Zee receives research support from the National Institutes of Health and is an Associate Editor of Frontiers in Neurootology and a member of the Editorial Board of The Cerebellum. He received speaker’s honoraria from Abbott, Sun pharmaceuticals and from the American Academy of Neurology.

Conflicts of interest

The authors declare that they have no conflict of interest.

Supplementary material

The patient shows right-beating horizontal-torsional nystagmus that increases without fixation, normal saccades, and impaired leftward smooth pursuit (MPG 7370 kb)

Bedside horizontal head impulse tests reveal small corrective catch-up saccades during stimulation of the left horizontal semicircular canal (MPG 2894 kb)

415_2013_6837_MOESM3_ESM.tif (1.7 mb)
During sinusoidal harmonic accelerations using a rotatory chair (CHARTR®, ICS Medical, IL, USA) at frequencies from 0.02 to 0.32 Hz and a fixed peak velocity of 50 O/s, the patient showed increased gains of the vestibulo-ocular reflex (TIFF 1760 kb)
415_2013_6837_MOESM4_ESM.jpg (370 kb)
Normal pure tone audiometry (JPEG 369 kb)
415_2013_6837_MOESM5_ESM.jpg (35 kb)
Normal bithermal caloric tests (JPEG 35 kb)


  1. 1.
    Zee DS, Yamazaki A, Butler PH, Gucer G (1981) Effects of ablation of flocculus and paraflocculus of eye movements in primate. J Neurophysiol 46(4):878–899PubMedGoogle Scholar
  2. 2.
    Ito M, Nisimaru N, Yamamoto M (1977) Specific patterns of neuronal connexions involved in the control of the rabbit’s vestibulo-ocular reflexes by the cerebellar flocculus. J Physiol 265(3):833–854PubMedGoogle Scholar
  3. 3.
    Straube A, Scheuerer W, Eggert T (1997) Unilateral cerebellar lesions affect initiation of ipsilateral smooth pursuit eye movements in humans. Ann Neurol 42(6):891–898. doi: 10.1002/ana.410420611 PubMedCrossRefGoogle Scholar
  4. 4.
    Tabata H, Yamamoto K, Kawato M (2002) Computational study on monkey VOR adaptation and smooth pursuit based on the parallel control-pathway theory. J Neurophysiol 87(4):2176–2189. doi: 10.1152/jn.00168.2001 PubMedGoogle Scholar
  5. 5.
    Yamazaki A, Zee DS (1979) Rebound nystagmus: EOG analysis of a case with a floccular tumour. B J Ophthalmol 63(11):782–786CrossRefGoogle Scholar
  6. 6.
    Halmagyi GM, Curthoys IS (1988) A clinical sign of canal paresis. Arch Neurol 45(7):737–739PubMedCrossRefGoogle Scholar
  7. 7.
    Choi KD, Oh SY, Park SH, Kim JH, Koo JW, Kim JS (2007) Head-shaking nystagmus in lateral medullary infarction: patterns and possible mechanisms. Neurology 68(17):1337–1344. doi: 10.1212/01.wnl.0000260224.60943.c2 PubMedCrossRefGoogle Scholar
  8. 8.
    Choi KD, Oh SY, Kim HJ, Koo JW, Cho BM, Kim JS (2007) Recovery of vestibular imbalances after vestibular neuritis. Laryngoscope 117(7):1307–1312. doi: 10.1097/MLG.0b013e31805c08ac PubMedCrossRefGoogle Scholar
  9. 9.
    Han BI, Oh HJ, Kim JS (2006) Nystagmus while recumbent in horizontal canal benign paroxysmal positional vertigo. Neurology 66(5):706–710. doi: 10.1212/01.wnl.0000201184.69134.23 PubMedCrossRefGoogle Scholar
  10. 10.
    Lee SH, Choi KD, Jeong SH, Oh YM, Koo JW, Kim JS (2007) Nystagmus during neck flexion in the pitch plane in benign paroxysmal positional vertigo involving the horizontal canal. J Neurol Sci 256(1–2):75–80. doi: 10.1016/j.jns.2007.02.026 PubMedCrossRefGoogle Scholar
  11. 11.
    Lee SH, Kim JS (2010) Benign paroxysmal positional vertigo. J Clin Neurol 6(2):51–63. doi: 10.3988/jcn.2010.6.2.51 PubMedCrossRefGoogle Scholar
  12. 12.
    Yang Y, Kim JS, Kim S, Kim YK, Kwak YT, Han IW (2009) Cerebellar hypoperfusion during transient global amnesia: an mri and oculographic study. J Clin Neurol 5(2):74–80. doi: 10.3988/jcn.2009.5.2.74 PubMedCrossRefGoogle Scholar
  13. 13.
    Moon IS, Kim JS, Choi KD, Kim MJ, Oh SY, Lee H, Lee HS, Park SH (2009) Isolated nodular infarction. Stroke 40(2):487–491. doi: 10.1161/STROKEAHA.108.527762 PubMedCrossRefGoogle Scholar
  14. 14.
    Jeong SH, Oh SY, Kim HJ, Koo JW, Kim JS (2010) Vestibular dysfunction in migraine: effects of associated vertigo and motion sickness. J Neurol 257(6):905–912. doi: 10.1007/s00415-009-5435-5 PubMedCrossRefGoogle Scholar
  15. 15.
    Choi KD, Oh SY, Kim HJ, Kim JS (2007) The vestibulo-ocular reflexes during head impulse in Wernicke’s encephalopathy. J Neurol Neurosurg Psychiatry 78(10):1161–1162. doi: 10.1136/jnnp.2007.121061 PubMedCrossRefGoogle Scholar
  16. 16.
    Kim JS, Kim HJ (2012) Inferior vestibular neuritis. J Neurol 259(8):1553–1560. doi: 10.1007/s00415-011-6375-4 PubMedCrossRefGoogle Scholar
  17. 17.
    Halmagyi GM, Aw ST, Cremer PD, Curthoys IS, Todd MJ (2001) Impulsive testing of individual semicircular canal function. Ann N Y Acad Sci 942:192–200PubMedCrossRefGoogle Scholar
  18. 18.
    Kim S, Lee HS, Kim JS (2010) Medial vestibulospinal tract lesions impair sacculo-collic reflexes. J Neurol 257(5):825–832. doi: 10.1007/s00415-009-5427-5 PubMedCrossRefGoogle Scholar
  19. 19.
    Kim S, Kim HJ, Kim JS (2011) Impaired sacculocollic reflex in lateral medullary infarction. Front Neurol 2:8. doi: 10.3389/fneur.2011.00008 PubMedCrossRefGoogle Scholar
  20. 20.
    Shin JY, Song HS, Koo JW, Lee HS, Kim JS (2009) Abnormal vestibular evoked myogenic potentials in medial medullary infarction. J Clin Neurol 5(2):101–103. doi: 10.3988/jcn.2009.5.2.101 PubMedCrossRefGoogle Scholar
  21. 21.
    Lisberger SG, Miles FA, Zee DS (1984) Signals used to compute errors in monkey vestibuloocular reflex: possible role of flocculus. J Neurophysiol 52(6):1140–1153PubMedGoogle Scholar
  22. 22.
    Kattah JC, Talkad AV, Wang DZ, Hsieh YH, Newman-Toker DE (2009) HINTS to diagnose stroke in the acute vestibular syndrome: three-step bedside oculomotor examination more sensitive than early MRI diffusion-weighted imaging. Stroke 40(11):3504–3510. doi: 10.1161/STROKEAHA.109.551234 PubMedCrossRefGoogle Scholar
  23. 23.
    Lee H, Sohn SI, Cho YW, Lee SR, Ahn BH, Park BR, Baloh RW (2006) Cerebellar infarction presenting isolated vertigo: frequency and vascular topographical patterns. Neurology 67(7):1178–1183. doi: 10.1212/01.wnl.0000238500.02302.b4 PubMedCrossRefGoogle Scholar
  24. 24.
    Cnyrim CD, Newman-Toker D, Karch C, Brandt T, Strupp M (2008) Bedside differentiation of vestibular neuritis from central “vestibular pseudoneuritis”. J Neurol Neurosurg Psychiatry 79(4):458–460. doi: 10.1136/jnnp.2007.123596 PubMedCrossRefGoogle Scholar
  25. 25.
    Tarnutzer AA, Berkowitz AL, Robinson KA, Hsieh YH, Newman-Toker DE (2011) Does my dizzy patient have a stroke? A systematic review of bedside diagnosis in acute vestibular syndrome. CMAJ: journal de l’Association medicale canadienne 183 (9):E571–E592. doi: 10.1503/cmaj.100174
  26. 26.
    Newman-Toker DE, Kattah JC, Alvernia JE, Wang DZ (2008) Normal head impulse test differentiates acute cerebellar strokes from vestibular neuritis. Neurology 70(24 Pt 2):2378–2385. doi: 10.1212/01.wnl.0000314685.01433.0d PubMedCrossRefGoogle Scholar
  27. 27.
    Crane BT, Tian JR, Demer JL (2000) Initial vestibulo-ocular reflex during transient angular and linear acceleration in human cerebellar dysfunction. Exp Brain Res 130(4):486–496PubMedCrossRefGoogle Scholar
  28. 28.
    Walker MF, Zee DS (1999) Directional abnormalities of vestibular and optokinetic responses in cerebellar disease. Ann N Y Acad Sci 871:205–220PubMedCrossRefGoogle Scholar
  29. 29.
    Baloh RW, Honrubia V, Konrad HR (1977) Ewald’s second law re-evaluated. Acta Otolaryngol 83(5–6):475–479PubMedCrossRefGoogle Scholar
  30. 30.
    Buttner-Ennever JA (1992) Patterns of connectivity in the vestibular nuclei. Ann N Y Acad Sci 656:363–378PubMedCrossRefGoogle Scholar
  31. 31.
    Galiana HL, Outerbridge JS (1984) A bilateral model for central neural pathways in vestibuloocular reflex. J Neurophysiol 51(2):210–241PubMedGoogle Scholar
  32. 32.
    Shin M, Moghadam SH, Sekirnjak C, Bagnall MW, Kolkman KE, Jacobs R, Faulstich M, du Lac S (2011) Multiple types of cerebellar target neurons and their circuitry in the vestibulo-ocular reflex. J Neurosci 31(30):10776–10786. doi: 10.1523/JNEUROSCI.0768-11.2011 PubMedCrossRefGoogle Scholar
  33. 33.
    Jorns-Haderli M, Straumann D, Palla A (2007) Accuracy of the bedside head impulse test in detecting vestibular hypofunction. J Neurol Neurosurg Psychiatry 78(10):1113–1118. doi: 10.1136/jnnp.2006.109512 PubMedCrossRefGoogle Scholar
  34. 34.
    Weber KP, Aw ST, Todd MJ, McGarvie LA, Curthoys IS, Halmagyi GM (2008) Head impulse test in unilateral vestibular loss: vestibulo-ocular reflex and catch-up saccades. Neurology 70(6):454–463. doi: 10.1212/01.wnl.0000299117.48935.2e PubMedCrossRefGoogle Scholar
  35. 35.
    Takemori S, Cohen B (1974) Loss of visual suppression of vestibular nystagmus after flocculus lesions. Brain Res 72(2):213–224PubMedCrossRefGoogle Scholar
  36. 36.
    Flandrin JM, Courjon JH, Jeannerod M, Schmid R (1983) Effects of unilateral flocculus lesions on vestibulo-ocular responses in the cat. Neuroscience 8(4):809–817PubMedCrossRefGoogle Scholar
  37. 37.
    Ito M, Highstein SM, Fukuda J (1970) Cerebellar inhibition of the vestibulo-ocular reflex in rabbit and cat and its blockage by picrotoxin. Brain Res 17(3):524–526PubMedCrossRefGoogle Scholar
  38. 38.
    Baker R, Precht W, Llinas R (1972) Cerebellar modulatory action on the vestibulo-trochlear pathway in the cat. Exp Brain Res 15(4):364–385PubMedCrossRefGoogle Scholar
  39. 39.
    Lee H, Yi HA, Lee SR, Lee SY, Park BR (2008) Ocular torsion associated with infarction in the territory of the anterior inferior cerebellar artery: frequency, pattern, and a major determinant. J Neurol Sci 269(1–2):18–23. doi: 10.1016/j.jns.2007.12.009 PubMedGoogle Scholar
  40. 40.
    Baier B, Bense S, Dieterich M (2008) Are signs of ocular tilt reaction in patients with cerebellar lesions mediated by the dentate nucleus? Brain 131(Pt 6):1445–1454. doi: 10.1093/brain/awn086 PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Hong-Kyun Park
    • 1
  • Ji-Soo Kim
    • 1
    Email author
  • Michael Strupp
    • 2
  • David S. Zee
    • 3
  1. 1.Department of Neurology, College of MedicineSeoul National University, Seoul National University Bundang HospitalSeongnamKorea
  2. 2.Department of Neurology, German Dizziness CenterLudwig-Maximilians-UniversityMunichGermany
  3. 3.Department of Neurology, Otolaryngology, Head and Neck Surgery, Neuroscience, and OphthalmologyJohns Hopkins University School of MedicineBaltimoreUSA

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