Journal of Neurology

, 257:136 | Cite as

Oculomotor disorders in adult-onset Still’s disease

  • Aasef G. ShaikhEmail author
  • Timothy C. Hain
  • David S. Zee
Letter to the Editors

A patient with adult-onset Still’s disease (AOSD)1 developed periodic horizontal micro-saccadic oscillations and periodic rapid clockwise torsional eye movements followed by counterclockwise torsional drifts (see video). Neuroimaging studies were normal. Tests for paraneoplastic antibodies were negative. Details of the clinical presentation and experimental methods are presented in supplementary material 1.

Horizontal saccades were faster than normal (supplementary material 2). There were bursts of horizontal saccadic oscillations without intersaccadic intervals (21.6 ± 0.4 Hz) and clockwise rapid torsional eye movement (top pole rotating towards the right ear) that had the same peak velocity-amplitude relationship as torsional quick phases of nystagmus (Fig.  1). These rapid torsional movements were followed by a drift (0.8 ± 0.2 deg/s) that brought the eyes to baseline. Low-frequency vertical and torsional oscillations were also seen (median: 3.4 and 3.1 Hz, respectively; Fig.  1b,...


Levetiracetam Torsional Oscillation Torsional Movement Burst Neuron AOSD Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported by grants from NIH EY01849 (DSZ), and the Georgia Birtman Grant Initiative (TCH) from the American Hearing Research Foundation and Northwestern Medical Foundation. Philanthropic funds from the vestibular laboratory supported AGS. We thank Mr. Dale Roberts for assistance.

Supplementary material

Supplementary material 1 (WMV 2375 kb)

415_2009_5308_MOESM2_ESM.doc (32 kb)
Supplementary material 2 (DOC 32 kb)
415_2009_5308_MOESM3_ESM.doc (162 kb)
Supplementary material 3 (DOC 161 kb)


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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Aasef G. Shaikh
    • 1
    Email author
  • Timothy C. Hain
    • 2
  • David S. Zee
    • 1
  1. 1.Department of NeurologyThe Johns Hopkins UniversityBaltimoreUSA
  2. 2.Department of NeurologyNorthwestern UniversityChicagoUSA

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