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The synergy between radiographic and macroscopic observation of skeletal lesions on dry bone

  • Lucie Biehler-GomezEmail author
  • Stefania Tritella
  • Federica Martino
  • Carlo Pietro Campobasso
  • Angélique Franchi
  • Riccardo Spairani
  • Francesco Sardanelli
  • Cristina Cattaneo
Original Article

Abstract

The diagnosis of bone lesions is a fundamental part of the study of skeletal remains, both in the archeological and forensic context. On the one side, the literature proved the relevance of radiography for the detection of bone lesions; on the other side, the careful macroscopic observation of the morphology of bone lesions is often underestimated. For this study, we examined and performed plain radiography on 14 skeletons of the CAL Milano Cemetery Skeletal Collection diagnosed with rheumatoid arthritis, diabetes, multiple myeloma, metastatic cancer, and osteomalacia to compare the macroscopic morphology and radiographic visualization of bone lesions. At least 200 osteolytic lesions and 65 areas of proliferative bone reaction (either spongiosclerotic or periosteal) were studied. We realized “comparative sets” of macroscopic pictures and radiographic imaging of the same skeletal elements to allow comparisons of detection and recognition of bone lesions. As a result, while trabecular lesions may be lost through naked eye observation, many lesions can also be unperceived on radiographs due to contrast, including periosteal reactions, osteolytic lesions, and spongiosclerosis. The aim of this research was to investigate the strengths and pitfalls of digital radiography and macroscopic analysis and to demonstrate the synergy of a complementary approach between the two methods for lesion analysis in dry bone.

Keywords

Forensic anthropology Bone pathology Radiographic imaging Rheumatoid arthritis Diabetes Metastatic carcinoma 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with animals performed by any of the authors.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Lucie Biehler-Gomez
    • 1
    Email author
  • Stefania Tritella
    • 2
  • Federica Martino
    • 3
  • Carlo Pietro Campobasso
    • 3
  • Angélique Franchi
    • 4
  • Riccardo Spairani
    • 5
  • Francesco Sardanelli
    • 2
    • 6
  • Cristina Cattaneo
    • 1
  1. 1.Laboratorio Di Antropologia E Odontologia Forense (LABANOF), Sezione Di Medicina Legale, Dipartimento Di Scienze Biomediche per La SaluteUniversità Degli Studi Di MilanoMilanItaly
  2. 2.Unit of RadiologyIRCCS Policlinico San DonatoSan Donato MilaneseItaly
  3. 3.Dipartimento di Medicina SperimentaleUniversità degli Studi della Campania “Luigi Vanvitelli”NaplesItaly
  4. 4.Forensic Medicine DepartmentUniversity Hospital of LyonLyonFrance
  5. 5.Post-Graduate School in RadiodiagnosticsUniversità degli Studi di MilanoMilanItaly
  6. 6.Department of Biomedical Sciences for HealthUniversità degli Studi di MilanoMilanItaly

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