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International Journal of Legal Medicine

, Volume 132, Issue 5, pp 1301–1304 | Cite as

Population data and phylogenetic structure of Han population from Jiangsu province of China on GlobalFiler STR loci

  • Atif Adnan
  • Xiaoni Zhan
  • Kadirya Kasim
  • Allah Rakha
  • Xing Jia Xin
Population Data

Abstract

Forensic statistical parameters based on allelic frequencies of commonly used short tandem repeats were estimated for the Han population of Jiangsu province from P.R. China. The 6-dye GlobalFiler™ PCR amplification kit incorporates 21 autosomal STRs, providing reliable DNA typing results with enhanced the power of discrimination. Here, we analyzed the GlobalFiler™ STR loci in 516 unrelated individuals from Jiangsu Han population. A total of 256 alleles were observed ranging between 5 and 35.2 repeat units, and SE33 showed the greatest power of discrimination (34 alleles) in Jiangsu Han population. Most of the loci were found to be in the Hardy-Weinberg equilibrium after the Bonferroni correction with the exception of D3S1358. The combined power of exclusion (CPE) was 0.999999996353609, and the combined match probability (CMP) was 3.64 × 10−25. Phylogenetic parameters including pairwise genetic distances showed that Han population living in Jiangsu had closest genetic relationship with other East Asian populations. The present study provides precise reference database for forensic applications and population genetic studies.

Keywords

Forensic population database Jiangsu Han China GlobalFiler™ 

Notes

Funding information

This project is supported by the National Natural Science Foundation of P.R. China (NSFC, No. 81471826), Ministry of Finance, P.R. China.

Compliance with ethical standards

All participants gave their informed consent in writing after the study aims and procedures were carefully explained to them in their own language. The study was approved by the ethical review board of the China Medical University, Shenyang Liaoning Province, People’s Republic of China, and in accordance with the standards of the Declaration of Helsinki.

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

414_2018_1815_MOESM1_ESM.xlsx (138 kb)
Supplementary Table 1 Allele frequencies and forensic parameters derived from 21 autosomal STR loci for the Han population from Jiangsu Province. (XLSX 138 kb)
414_2018_1815_MOESM2_ESM.xlsx (11 kb)
Supplementary Table 2 p-values from exact tests for linkage equilibrium (LE) employing pairwise combinations of all 21 STR loci in Han population from Jiangsu Province. (XLSX 10 kb)
414_2018_1815_MOESM3_ESM.xlsx (8 kb)
Supplementary Table 3 Linkage disequilibrium test between loci located on the same chromosome in Han population from Jiangsu Province (XLSX 8 kb)
414_2018_1815_MOESM4_ESM.xlsx (14 kb)
Supplementary Table 4 Genetic distance (FST) and associated p-values for population differentiation between the Uzbek population and other published populations (XLSX 13 kb)
414_2018_1815_MOESM5_ESM.xlsx (9 kb)
Supplementary Table 5 Nei’s pairwise genetic distance between Han population from Jiangsu Province of China and other populations at the 21 Globalfiler autosomal STR loci (XLSX 8 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Forensic Genetics, School of Forensic MedicineChina Medical UniversityShenyangPeople’s Republic of China
  2. 2.Department of Forensic SciencesUniversity of Health SciencesLahorePakistan

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