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Toxicity of high uranium doses in broilers and protection with mineral adsorbents

  • Branislava MitrovićEmail author
  • Mirjana Stojanović
  • Živko Sekulić
  • Velibor Andrić
  • Mihajlo Vićentijević
  • Borjana Vranješ
Original Article
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Abstract

The aim of this study was to determine the uranium distribution and histopathological changes in broiler organs (kidney, liver, and brain) and muscle after 7 days of contamination with high doses of uranyl nitrate hexahydrate (UN), and the protective efficiency of three different mineral adsorbents (organobentonite, organozeolite, and sepiolite). During the 7 days, the UN administration was 50 mg per day, and administration of adsorbents was 2 g per day immediately after UN. In control group where broilers received only UN, histopathological changes such as necrosis of intestinal villi, oedema, vacuolisation and abruption of epithelial cells in renal tubules, oedema and vacuolisation of the cytoplasm of hepatocytes, and dystrophic changes in the neurons of the medulla oblongata were observed. In contrast, when the adsorbents organobentonite, organozeolite, and sepiolite were administered, no histopathological changes were observed in liver and brain. The investigated adsorbents showed the highest protective effects in liver (80–92%), compared to the kidney (77–86%), brain (37–64%), and meat (31–63%).

Keywords

Uranyl nitrate Broilers Toxicity Histopathological changes Adsorbents 

Notes

Acknowledgements

This paper was part of the projects “Development of technology and products based on mineral raw materials and biomass for protecting the food resources” (No. TR31003) and “Development of technological processes for obtaining of ecological materials based on non-metallic minerals” (No. TR034013) financed by the Ministry of Education, Science and Technological Development of the Republic of Serbia (2011–2019).

Compliance with ethical standards

Conflict of interest

Al authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Branislava Mitrović
    • 1
    Email author
  • Mirjana Stojanović
    • 2
  • Živko Sekulić
    • 2
  • Velibor Andrić
    • 1
  • Mihajlo Vićentijević
    • 3
  • Borjana Vranješ
    • 1
  1. 1.Faculty of Veterinary MedicineBelgradeSerbia
  2. 2.Institute for Technology of Nuclear and Other Mineral Row MaterialsUniversity of BelgradeBelgradeSerbia
  3. 3.Science Institute of Veterinary Medicine of SerbiaBelgradeSerbia

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