Validation of a system of models for plutonium decorporation therapy
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A recently proposed system of models for plutonium decorporation (SPD) was developed using data from an individual occupationally exposed to plutonium via a wound [from United States Transuranium and Uranium Registries (USTUR) Case 0212]. The present study evaluated the SPD using chelation treatment data, urine measurements, and post-mortem plutonium activities in the skeleton and liver from USTUR Case 0269. This individual was occupationally exposed to moderately soluble plutonium via inhalation and extensively treated with chelating agents. The SPD was linked to the International Commission on Radiological Protection (ICRP) Publication 66 Human Respiratory Tract Model (HRTM) and the ICRP Publication 30 Gastrointestinal Tract model to evaluate the goodness-of-fit to the urinary excretion data and the predictions of post-mortem plutonium retention in the skeleton and liver. The goodness-of-fit was also evaluated when the SPD was linked to the ICRP Publication 130 HRTM and the ICRP Publication 100 Human Alimentary Tract Model. The present study showed that the proposed SPD was useful for fitting the entire, chelation-affected and non-affected, urine bioassay data, and for predicting the post-mortem plutonium retention in the skeleton and liver at time of death, 38.5 years after the accident. The results of this work are consistent with the conclusion that Ca-EDTA is less effective than Ca-DTPA for enhancing urinary excretion of plutonium.
KeywordsPlutonium Chelating agents Decorporation therapy Biokinetic modeling Human data United States Transuranium and Uranium Registries
The authors acknowledge the many helpful comments and suggestions from anonymous reviewers and the editor. Funding was provided by the Coordination for the Improvement of Higher Level Personnel (CAPES, Brazil), under Grant award no. 013355/2013-09 to S.D., and by the U.S. Department of Energy, Office of Domestic and International Health Studies (AU-13), under Grant award no. DE-HS0000073 to the USTUR. This study was performed as a part of the USTUR research program, which was reviewed and approved by Washington State University Institutional Review Board no. 11573.
Compliance with ethical standards
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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