Unfolded Protein Response in Acute Respiratory Distress Syndrome
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The endothelial layer of the lung microvasculature regulates the traffic of blood fluid, electrolytes, and proteins crosswise the vascular wall. Inflammatory stimuli partner with multifarious messengers to reform the junction and adhesion proteins of the cytoskeleton, which in turn causes endothelial anomalies. Endothelial barrier dysfunction (EBD) due to lung injury increases the permeability across the endothelial and epithelial barriers of the lung and produces an influx of protein-rich edema fluid, endothelial hyperpermeability, and pulmonary dysfunction. ARDS represents the manifestation of severe EBD complications in hospitalized individuals. It is associated with non-hydrostatic pulmonary edema and respiratory abnormalities, often associated with lethal outcomes. Indeed, the unacceptable high mortality rates of ARDS suggest that the exploration of new therapeutic avenues towards this syndrome is an urgent need. The discovery of the molecular components that regulate vascular...
Dr. Barabutis’ is supported by the R&D, Research Competitiveness Subprogram (RCS) of the Louisiana Board of Regents through the Board of Regents Support Fund (LEQSF(2019-22)-RD-A-26), as well as by the NIGMS/NIH (5 P20GM103424-15, 3 P20GM103424-15S1).
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Conflict of interest
All authors declare that have no conflict of interest.
This article does not contain any studies with human participants or animals performed by any of the authors.